FANCD2 and UBE2T

Data Source:
BioGRID (enzymatic study)

		FANCD2	UBE2T
Description		FA complementation group D2	ubiquitin conjugating enzyme E2 T
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GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding DNA Polymerase Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Intra-S DNA Damage Checkpoint Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway	Protein Polyubiquitination DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein K29-linked Ubiquitination Interstrand Cross-link Repair Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases		Fanconi anemia
GWAS		Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)	Breast cancer ( 23535733) Celiac disease ( 23936387)
Interacting Genes		28 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1	22 interacting genes: AMFR ARIH2 BRCA1 CDK2 CHEK1 FANCD2 FANCL LNX2 MARCHF5 MGRN1 PCGF2 PRKCG PRKN RNF128 RNF144B RNF31 RNF4 ROCK1 RPS6KA1 TRIM27 UBA1 UBA6
Entrez ID		2177	29089
HPRD ID		01968	13704
Ensembl ID		ENSG00000144554	ENSG00000077152
Uniprot IDs		Q9BXW9	A0A024R9A9 Q9NPD8
PDB IDs		6VAA 6VAD 6VAE 6VAF	1YH2 4CCG 5NGZ 5OJJ 6R75
Enriched GO Terms of Interacting Partners?
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