ALDH2 and EIF6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ALDH2	EIF6
Description		aldehyde dehydrogenase 2 family member	eukaryotic translation initiation factor 6
Image
GO Annotations	Cellular Component	Mitochondrial Matrix Extracellular Exosome	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome
	Molecular Function	Aldehyde Dehydrogenase (NAD+) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Electron Transfer Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity NAD Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Catabolic Process Ethanol Oxidation Electron Transport Chain	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Metabolism of serotonin Ethanol oxidation
Drugs		NADH Guanidine Disulfiram Daidzin Crotonaldehyde	Copper
Diseases		Acute alcohol sensitivity
GWAS		Alcohol consumption ( 21270382) Alcohol consumption (drinkers vs non-drinkers) ( 28485404 31959922) Alcohol consumption (drinks per week) ( 31959922) Alcohol consumption (max-drinks) ( 24277619 29460428) Alcohol dependence ( 24277619) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Blood pressure ( 21572416) Body mass index ( 26426971 24861553 28892062) Coffee consumption ( 31959922 29367735) Coronary artery disease ( 30402224 33020668) Coronary heart disease ( 23364394 21971053) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 26390057 25249183) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 23364009 21372407) Esophageal cancer ( 19698717) Estimated glomerular filtration rate ( 31015462) Fish intake frequency ( 31959922) Gout ( 32238385) Gout (combined type) ( 32238385) Gout vs. Hyperuricemia ( 31289104) Green tea consumption ( 31959922) Height ( 31562340) Hematological and biochemical traits ( 20139978) Hemoglobin levels ( 32327693) Hypertension ( 25249183) Inflammatory bowel disease ( 26192919 28067908) Intracranial aneurysm ( 22286173) Ischemic stroke ( 26708676) Ischemic stroke (small artery occlusion) ( 26708676) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 20139978) Metabolic syndrome ( 28371326) Milk consumption ( 31959922) Myocardial infarction ( 30226566 24916648) Natto consumption ( 31959922) Oral cavity and pharyngeal cancer ( 21437268) Primary biliary cholangitis ( 26394269) Psoriasis ( 25854761) Renal function-related traits (sCR) ( 22797727) Renal overload gout ( 32238385) Renal underexcretion gout ( 32238385) Response to alcohol consumption (flushing response) ( 24277619 29460428) Serum alpha1-antitrypsin levels ( 26174136) Serum uric acid levels ( 29408531 29124443) Small vessel stroke (CCSp classification) ( 32047268) Smoking behaviour (cigarettes smoked per day) ( 31089300) Stroke (ischemic) ( 23041239) Sweet taste preference ( 32572145) Systolic blood pressure ( 26390057 25249183) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tofu consumption ( 31959922) Triglycerides ( 22171074 26582766) Type 2 diabetes ( 32499647) Urate levels ( 31578528) Yoghurt consumption ( 31959922)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: ALDH1A1 APP CRMP1 DENND10P1 EIF6 ERG28 HSPB2 HSPD1 HSPE1 IGSF21 RPL13A SIRT3 SLC35F6 UNC119	41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26
Entrez ID		217	3692
HPRD ID		00003	04221
Ensembl ID		ENSG00000111275	ENSG00000242372
Uniprot IDs		A0A384NPN7 P05091	P56537
PDB IDs		1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8 4KWF 4KWG 5L13	6LQM 6LSR 6LSS 6LU8
Enriched GO Terms of Interacting Partners?
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