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F10 and PLAT
Data Source:
BioGRID
(pull down)
HPRD
(in vitro)
F10
PLAT
Description
coagulation factor X
plasminogen activator, tissue type
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Lumen
Plasma Membrane
Intrinsic Component Of External Side Of Plasma Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Cell Surface
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Serine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Serine-type Endopeptidase Activity
Signaling Receptor Binding
Protein Binding
Phosphoprotein Binding
Biological Process
Proteolysis
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Blood Coagulation
Blood Coagulation, Extrinsic Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Kinase B Signaling
Cellular Protein Modification Process
Proteolysis
Blood Coagulation
Smooth Muscle Cell Migration
Plasminogen Activation
Fibrinolysis
Negative Regulation Of Proteolysis
Platelet-derived Growth Factor Receptor Signaling Pathway
Pathways
Extrinsic Pathway of Fibrin Clot Formation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Gamma-carboxylation of protein precursors
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Removal of aminoterminal propeptides from gamma-carboxylated proteins
Defective factor IX causes thrombophilia
Defective cofactor function of FVIIIa variant
Defective F9 variant does not activate FX
Signaling by PDGF
Dissolution of Fibrin Clot
Drugs
Antihemophilic factor, human recombinant
Coagulation factor VIIa Recombinant Human
Coagulation Factor IX (Recombinant)
Fondaparinux
Heparin
Enoxaparin
gamma-carboxy-L-glutamic acid
4-[(5-CHLOROINDOL-2-YL)SULFONYL]-2-(2-METHYLPROPYL)-1-[[5-(PYRIDIN-4-YL)PYRIMIDIN-2-YL]CARBONYL]PIPERAZINE
SSR-126517E
LY-517717
Rivaroxaban
Lanoteplase
Idraparinux
rNAPc2
Apixaban
Otamixaban
Eribaxaban
(2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [1-(1-AMINO-ISOQUINOLIN-7-YLMETHYL)-2-OXO-PYRROLDIN-3-YL]-AMIDE
2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE
GW-813893
2-({4-[(5-CHLORO-1H-INDOL-2-YL)SULFONYL]PIPERAZIN-1-YL}CARBONYL)THIENO[3,2-B]PYRIDINE 4-OXIDE
N-((1R,2S)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE
N-((1R,2R)-2-(5-CHLORO-1H-INDOLE-2-CARBOXAMIDO)CYCLOHEXYL)-5-METHYL-4,5,6,7-TETRAHYDROTHIAZOLO[5,4-C]PYRIDINE-2-CARBOXAMIDE
N-(2-(((5-CHLORO-2-PYRIDINYL)AMINO)SULFONYL)PHENYL)-4-(2-OXO-1(2H)-PYRIDINYL)BENZAMIDE
5-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1H-1,2,4-TRIAZOLE-3-SULFONAMIDE
5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE
6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE
6-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-(4-MORPHOLINYL)-2-OXO ETHYL]-2-OXO-3-PYRROLIDINYL}-2-NAPHTHALENESULFONAMIDE
5-Chloro-N-{(3S)-1-[(2S)-1-(4-morpholinyl)-1-oxo-2-propanyl]-2-oxo-3-pyrrolidinyl}-1H-indole-2-sulfonamide
5-chloro-N-[(3R)-1-(2-{[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]amino}-2-oxoethyl)pyrrolidin-3-yl]thiophene-2-carboxamide
5-Chloro-thiophene-2-carboxylic acid ((3S,4S)-1-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-methyl}-4-hydroxy-pyrrolidin-3-yl)-amide
N-(1-ISOPROPYLPIPERIDIN-4-YL)-1-(3-METHOXYBENZYL)-1H-INDOLE-2-CARBOXAMIDE
1-{2-[(4-CHLOROPHENYL)AMINO]-2-OXOETHYL}-N-(1-ISOPROPYLPIPERIDIN-4-YL)-1H-INDOLE-2-CARBOXAMIDE
5-CHLORO-THIOPHENE-2-CARBOXYLIC ACID ((3S,4S)-4-FLUORO- 1-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYLCARBAMOYL]-METHYL}-PYRROLIDIN-3-YL)-AMIDE
5-CHLORO-N-(2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO)ETHYL)THIOPHENE-2-CARBOXAMIDE
5-CHLORO-N-((1R,2S)-2-(4-(2-OXOPYRIDIN-1(2H)-YL)BENZAMIDO) CYCLOPENTYL)THIOPHENE-2-CARBOXAMIDE
THIENO[3,2-B]PYRIDINE-2-SULFONIC ACID [2-OXO-1-(1H-PYRROLO[2,3-C]PYRIDIN-2-YLMETHYL)-PYRROLIDIN-3-YL]-AMIDE
3-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE
4-{[(E)-2-(5-CHLOROTHIEN-2-YL)VINYL]SULFONYL}-1-(1H-PYRROLO[3,2-C]PYRIDIN-2-YLMETHYL)PIPERAZIN-2-ONE
4-({4-[(6-CHLORO-1-BENZOTHIEN-2-YL)SULFONYL]-2-OXOPIPERAZIN-1-YL}METHYL)BENZENECARBOXIMIDAMIDE
4-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE
1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE
Edoxaban
Turoctocog alfa
Protamine sulfate
Bemiparin
Kappadione
Antithrombin Alfa
Betrixaban
Nafamostat
Protein S human
Coagulation factor VII human
Anti-inhibitor coagulant complex
Coagulation Factor IX Human
Antihemophilic factor human
Albutrepenonacog alfa
Emicizumab
Nonacog beta pegol
Lonoctocog alfa
Moroctocog alfa
Turoctocog alfa pegol
Aminocaproic acid
Iloprost
Human C1-esterase inhibitor
5-(DIMETHYLAMINO)-2-NAPHTHALENESULFONIC ACID
Dexibuprofen
Conestat alfa
Diseases
GWAS
Bipolar disorder (
31043756
)
Blood protein levels (
30072576
29875488
28240269
)
Factor VII (
17903294
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Blood protein levels (
30072576
)
Plasma plasminogen activator levels (
24578379
)
Systemic lupus erythematosus (
28714469
)
Interacting Genes
21 interacting genes:
APOH
F3
F5
F7
F8
GAD2
GGCX
H1-2
MGST3
NBPF19
NOTCH2NLA
PLAT
PLG
PRKAB1
PROS1
SERPINA10
SERPINA5
SERPINB6
SERPINB8
TFPI
UBQLN2
27 interacting genes:
ANXA2
APP
CALR
CKAP4
CLEC3B
F10
FGA
FN1
GRIN1
HMGB1
KRT8
LAMA1
LAMA3
LRP1
LRP1B
MAPK1
MAPK3
MTDH
PDGFC
PLAU
PLG
SERPINA5
SERPINE1
SERPING1
SERPINI1
SPARC
VDAC1
Entrez ID
2159
5327
HPRD ID
01966
01419
Ensembl ID
ENSG00000126218
ENSG00000104368
Uniprot IDs
P00742
Q5JVE7
Q5JVE8
B4DN26
P00750
PDB IDs
1C5M
1EZQ
1F0R
1F0S
1FAX
1FJS
1FXY
1G2L
1G2M
1HCG
1IOE
1IQE
1IQF
1IQG
1IQH
1IQI
1IQJ
1IQK
1IQL
1IQM
1IQN
1KSN
1LPG
1LPK
1LPZ
1LQD
1MQ5
1MQ6
1MSX
1NFU
1NFW
1NFX
1NFY
1NL8
1P0S
1V3X
1WU1
1XKA
1XKB
1Z6E
2BMG
2BOH
2BOK
2BQ6
2BQ7
2BQW
2CJI
2D1J
2EI6
2EI7
2EI8
2FZZ
2G00
2GD4
2H9E
2J2U
2J34
2J38
2J4I
2J94
2J95
2JKH
2P16
2P3F
2P3T
2P3U
2P93
2P94
2P95
2PHB
2PR3
2Q1J
2RA0
2UWL
2UWO
2UWP
2VH0
2VH6
2VVC
2VVU
2VVV
2VWL
2VWM
2VWN
2VWO
2W26
2W3I
2W3K
2WYG
2WYJ
2XBV
2XBW
2XBX
2XBY
2XC0
2XC4
2XC5
2Y5F
2Y5G
2Y5H
2Y7X
2Y7Z
2Y80
2Y81
2Y82
3CEN
3CS7
3ENS
3FFG
3HPT
3IIT
3K9X
3KL6
3KQB
3KQC
3KQD
3KQE
3LIW
3M36
3M37
3Q3K
3SW2
3TK5
3TK6
4A7I
4BTI
4BTT
4BTU
4Y6D
4Y71
4Y76
4Y79
4Y7A
4Y7B
4ZH8
4ZHA
5JQY
5JTC
5JZ8
5JZU
5K0H
5VOE
5VOF
6Q9F
6Q9I
6RK9
1A5H
1BDA
1PK2
1PML
1RTF
1TPG
1TPK
1TPM
1TPN
5BRR
5ZLZ
Enriched GO Terms of Interacting Partners
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