EPHA8 and DARS2

Data Source:
BioGRID (two hybrid)

		EPHA8	DARS2
Description		EPH receptor A8	aspartyl-tRNA synthetase 2, mitochondrial
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection Receptor Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding	TRNA Binding Aspartate-tRNA Ligase Activity Protein Binding ATP Binding Protein Homodimerization Activity Aspartate-tRNA(Asn) Ligase Activity
	Biological Process	Substrate-dependent Cell Migration Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Cellular Response To Follicle-stimulating Hormone Stimulus	TRNA Aminoacylation For Protein Translation TRNA Aminoacylation Mitochondrial Asparaginyl-tRNA Aminoacylation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	Mitochondrial tRNA aminoacylation
Drugs		Fostamatinib	Aspartic acid
Diseases			Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation (LBSL)
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746	15 interacting genes: AIMP2 ALDH18A1 AOC3 CDIPT COL8A2 CYB561 DPYSL5 EPHA8 FETUB KARS1 PLP2 THSD7B TMEM239 TSPAN33 UNC50
Entrez ID		2046	55157
HPRD ID		01493	07677
Ensembl ID		ENSG00000070886	ENSG00000117593
Uniprot IDs		P29322	Q6PI48 Q9H9J7
PDB IDs		1UCV 1X5L 3KUL	4AH6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?