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EP300 and POLB
Data Source:
BioGRID
(pull down, enzymatic study)
EP300
POLB
Description
E1A binding protein p300
DNA polymerase beta
Image
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromosome
Cytosol
Protein-DNA Complex
Nucleus
Nucleoplasm
Cytoplasm
Microtubule
Spindle Microtubule
Protein-containing Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Activating Transcription Factor Binding
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor
Protein Binding
Beta-catenin Binding
Protein C-terminus Binding
Transcription Factor Binding
Zinc Ion Binding
Acetyltransferase Activity
Transferase Activity, Transferring Acyl Groups
Chromatin DNA Binding
Activating Transcription Factor Binding
Nuclear Hormone Receptor Binding
Tau Protein Binding
Androgen Receptor Binding
NF-kappaB Binding
Peptide-lysine-N-acetyltransferase Activity
Protein Propionyltransferase Activity
Pre-mRNA Intronic Binding
STAT Family Protein Binding
Peptide Butyryltransferase Activity
Histone Crotonyltransferase Activity
Histone Butyryltransferase Activity
Damaged DNA Binding
DNA-directed DNA Polymerase Activity
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Protein Binding
Microtubule Binding
Lyase Activity
Enzyme Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Somitogenesis
Thigmotaxis
Behavioral Defense Response
Stimulatory C-type Lectin Receptor Signaling Pathway
Regulation Of Glycolytic Process
Transcription-coupled Nucleotide-excision Repair
Regulation Of Transcription, DNA-templated
Protein Acetylation
Internal Protein Amino Acid Acetylation
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Nervous System Development
Heart Development
Skeletal Muscle Tissue Development
Learning Or Memory
Circadian Rhythm
Animal Organ Morphogenesis
Regulation Of Autophagy
Macrophage Derived Foam Cell Differentiation
Regulation Of Mitochondrion Organization
Positive Regulation Of Neuron Projection Development
Viral Process
Histone Acetylation
Protein Deubiquitination
N-terminal Peptidyl-lysine Acetylation
Protein Phosphopantetheinylation
Internal Peptidyl-lysine Acetylation
Peptidyl-lysine Acetylation
B Cell Differentiation
Platelet Formation
Lung Development
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Protein-containing Complex Assembly
Protein Destabilization
Positive Regulation Of Protein Binding
Positive Regulation Of Type I Interferon Production
Cellular Response To UV
Multicellular Organism Growth
Megakaryocyte Development
Swimming
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Response To Estrogen
Positive Regulation By Host Of Viral Transcription
Histone H4 Acetylation
Histone H2B Acetylation
Fat Cell Differentiation
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gluconeogenesis
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Regulation Of Cell Cycle
Face Morphogenesis
Regulation Of Androgen Receptor Signaling Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Peptidyl-lysine Propionylation
Regulation Of Tubulin Deacetylation
Peptidyl-lysine Crotonylation
Peptidyl-lysine Butyrylation
Regulation Of Cellular Response To Heat
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Signal Transduction By P53 Class Mediator
Beta-catenin-TCF Complex Assembly
Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
In Utero Embryonic Development
DNA-dependent DNA Replication
DNA Repair
Base-excision Repair
Base-excision Repair, Base-free Sugar-phosphate Removal
Base-excision Repair, Gap-filling
Base-excision Repair, DNA Ligation
Pyrimidine Dimer Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair Via Nonhomologous End Joining
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Salivary Gland Morphogenesis
Aging
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Somatic Hypermutation Of Immunoglobulin Genes
Protein Deubiquitination
Response To Ethanol
Lymph Node Development
Spleen Development
Homeostasis Of Number Of Cells
Neuron Apoptotic Process
Response To Hyperoxia
Immunoglobulin Heavy Chain V-D-J Recombination
DNA Biosynthetic Process
Pathways
Regulation of gene expression by Hypoxia-inducible Factor
RORA activates gene expression
Polo-like kinase mediated events
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
PPARA activates gene expression
PPARA activates gene expression
Formation of the beta-catenin:TCF transactivating complex
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
HATs acetylate histones
Attenuation phase
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
SUMOylation of transcription cofactors
Circadian Clock
B-WICH complex positively regulates rRNA expression
Activation of anterior HOX genes in hindbrain development during early embryogenesis
CD209 (DC-SIGN) signaling
Metalloprotease DUBs
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Methylation
PI5P Regulates TP53 Acetylation
Activation of the TFAP2 (AP-2) family of transcription factors
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
Regulation of RUNX3 expression and activity
RUNX3 regulates p14-ARF
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NGF-stimulated transcription
NGF-stimulated transcription
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
FOXO-mediated transcription of cell death genes
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Regulation of FOXO transcriptional activity by acetylation
Regulation of FOXO transcriptional activity by acetylation
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
PCNA-Dependent Long Patch Base Excision Repair
Ub-specific processing proteases
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Drugs
Cytarabine
Iron
dATP
(1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
Ferrous gluconate
Ferrous succinate
Ferrous ascorbate
Ferrous fumarate
Ferrous glycine sulfate
Diseases
Rubinstein-Taybi syndrome
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Crohn's disease (
22936669
)
General risk tolerance (MTAG) (
30643258
)
Neuroticism (
29255261
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Schizophrenia (
28991256
25056061
29483656
)
Type 2 diabetes (
30297969
)
Plasma parathyroid hormone levels (
30134803
)
Plasma plasminogen activator levels (
24578379
)
Interacting Genes
374 interacting genes:
ABL1
ACSM5
ACTA2
ACTB
AHR
AKT1
ALKBH4
ALX1
APEX1
AR
ARHGDIA
ARNT
ARNTL
ARSF
ASCL1
ASH2L
ATF4
ATF5
ATR
AUTS2
BAG6
BCAS2
BCL3
BCL6
BRCA1
BRMS1
C1R
CALCOCO1
CARM1
CCNB1
CCND1
CDK1
CDK2
CDT1
CDX2
CEBPA
CEBPB
CEBPD
CFH
CHD4
CITED1
CITED2
CITED4
CLOCK
CNOT4
COPS2
COPS6
CREBBP
CRX
CTBP1
CTBP2
CTF1
CTNNB1
CXCL8
CXXC1
DAO
DBP
DDIT3
DDX24
DDX5
DECR2
DEK
DTX1
DUX4
E2F1
E2F5
EEF1A1
EEF2
EGR1
EID1
EID2
ELF3
ELK1
ELL
EMB
EPAS1
EPO
ESR1
ESR2
ETS1
ETS2
ETV1
ETV4
FBXL5
FEN1
FHL2
FOSB
FOSL1
FOSL2
FOXO3
FOXP3
GAA
GABPA
GATA2
GATA4
GATA5
GATA6
GCKR
GLUL
GOLGA2
GPBP1
GPS2
GRB2
GRIP1
GTF2B
H1-1
H1-3
H2AC20
H2AC21
H2AC4
H2BC21
H2BC3
H3-3A
H3-4
H3C1
H3C14
H4-16
H4C1
H4C14
H4C9
HAND2
HBP1
HDAC1
HDAC3
HDAC6
HEMGN
HERC1
HIF1A
HMGB1
HMGN1
HMGN2
HNF1A
HNRNPU
HNRNPUL1
HOXA10
HOXB1
HOXB2
HOXB3
HOXB4
HOXB6
HOXB7
HOXB9
HOXD10
HOXD4
HPS6
HSP90AA2P
ILF2
ILF3
IMMT
ING1
ING2
ING4
ING5
IRF1
IRF2
IRF3
IRF5
IRF7
ITIH3
JDP2
JMY
JUN
JUNB
JUND
KAT2A
KAT2B
KAT5
KCTD5
KDM2A
KLF1
KLF13
KLF2
KLF4
KLF5
KPNA2
KRT18
LEF1
MAF
MAGED1
MAML1
MAP2K1
MAP3K5
MAPK1
MAPK8
MAPT
MAX
MCL1
MCM2
MCM3
MCM3AP
MCM4
MCM5
MDC1
MDM2
MDM4
MEF2A
MEF2C
MEF2D
MGMT
MITF
MN1
MORF4L1
MPG
MRE11
MSH6
MSTO1
MTOR
MYB
MYBL2
MYC
MYOD1
N4BP2
NAP1L1
NAP1L4
NBN
NCOA1
NCOA2
NCOA3
NCOA6
NEDD1
NEIL2
NEUROD1
NFATC1
NFATC2
NFYB
NOTCH1
NOXA1
NPAS2
NPM1
NR1H4
NR1I2
NR2F2
NR4A1
NUP98
NUPR1
OLIG2
ORC2
PAK2
PAX5
PAX6
PAX8
PAXIP1
PCK2
PCNA
PDHX
PELP1
PIAS1
PIAS3
PIN1
PLAGL1
PLG
PLSCR1
PLSCR2
PML
POLB
POLD2
POLI
POU3F2
PPARA
PPARD
PPARG
PPP2R5C
PRKCA
PRKCB
PRKCD
PRKDC
PRMT1
PROX1
PTMA
RACK1
RAD23A
RAD50
RAN
RB1
RBM14
RECQL4
REL
RELA
RORA
RPL27
RPS6KA5
RPS6KB1
RPS6KB2
RUNX1
RUNX2
RUNX3
RUVBL2
SATB1
SAV1
SELENOP
SENP3
SERTAD1
SET
SETD1A
SIRT1
SIRT2
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMAD5
SMAD7
SNAI1
SNIP1
SNW1
SOX9
SP1
SP3
SPHK1
SPIB
SREBF1
SREBF2
SRY
SS18
SS18L1
STAT1
STAT2
STAT3
STAT5A
STAT5B
STAT6
SUB1
SUMO2
SUV39H1
TACC2
TADA3
TAF1B
TAL1
TCF12
TCF3
TCF4
TCF7L2
TDG
TERF2
TFAP2A
TGFB1I1
TGS1
THPO
TINAGL1
TNIP2
TP53
TP53BP1
TP63
TP73
TRAF2
TRERF1
TRIP4
TSG101
TWIST1
UBC
UBE2D1
UBE2I
UBQLN1
UBTF
USF2
VPS18
WDR59
WDR82
XRCC6
YWHAZ
YY1
ZBTB16
ZBTB17
ZBTB48
ZBTB49
ZBTB7B
ZBTB8A
ZC3H12A
ZEB1
ZFPM2
ZNF148
ZNF76
ZRANB2
19 interacting genes:
APEX1
BRCA1
EP300
HUS1
HUWE1
KAT7
NEIL1
PCNA
PNKP
PRKCA
RAD1
RAD9A
SRPK2
STUB1
TAF1D
TLE1
TPP2
WRN
XRCC1
Entrez ID
2033
5423
HPRD ID
04078
07517
Ensembl ID
ENSG00000100393
ENSG00000070501
Uniprot IDs
Q09472
Q7Z6C1
B7Z1W5
P06746
PDB IDs
1L3E
1P4Q
2K8F
2MH0
2MZD
3BIY
3I3J
3IO2
3P57
3T92
4BHW
4PZR
4PZS
4PZT
5BT3
5KJ2
5LKT
5LKU
5LKX
5LKZ
5LPK
5LPM
5NU5
5XZC
6DS6
6FGN
6FGS
6GYR
6GYT
6K4N
6PF1
6PGU
6V8B
6V8K
6V8N
6V90
1BPX
1BPY
1BPZ
1MQ2
1MQ3
1TV9
1TVA
1ZJM
1ZJN
1ZQA
1ZQB
1ZQC
1ZQD
1ZQE
1ZQF
1ZQG
1ZQH
1ZQI
1ZQJ
1ZQK
1ZQL
1ZQM
1ZQN
1ZQO
1ZQP
1ZQQ
1ZQR
1ZQS
1ZQT
2FMP
2FMQ
2FMS
2I9G
2ISO
2ISP
2P66
2PXI
3C2K
3C2L
3C2M
3GDX
3ISB
3ISC
3ISD
3JPN
3JPO
3JPP
3JPQ
3JPR
3JPS
3JPT
3LK9
3MBY
3OGU
3RH4
3RH5
3RH6
3RJE
3RJF
3RJG
3RJH
3RJI
3RJJ
3RJK
3TFR
3TFS
4DO9
4DOA
4DOB
4DOC
4F5N
4F5O
4F5P
4F5Q
4F5R
4GXI
4GXJ
4GXK
4JWM
4JWN
4KLD
4KLE
4KLF
4KLG
4KLH
4KLI
4KLJ
4KLL
4KLM
4KLO
4KLQ
4KLS
4KLT
4KLU
4LVS
4M2Y
4M47
4M9G
4M9H
4M9J
4M9L
4M9N
4MF2
4MF8
4MFA
4MFC
4MFF
4NLK
4NLN
4NLZ
4NM1
4NM2
4NXZ
4NY8
4O5C
4O5E
4O5K
4O9M
4P2H
4PGQ
4PGX
4PGY
4PH5
4PHA
4PHD
4PHE
4PHP
4PPX
4R63
4R64
4R65
4R66
4RPX
4RPY
4RPZ
4RQ0
4RQ1
4RQ2
4RQ3
4RQ4
4RQ5
4RQ6
4RQ7
4RQ8
4RT2
4RT3
4TUP
4TUQ
4TUR
4TUS
4UAW
4UAY
4UAZ
4UB1
4UB2
4UB3
4UB4
4UB5
4UBB
4UBC
4YMM
4YMN
4YMO
4YN4
4Z6C
4Z6D
4Z6E
4Z6F
5BOL
5BOM
5BPC
5DB6
5DB7
5DB8
5DB9
5DBA
5DBB
5DBC
5EOZ
5HHH
5HHI
5J0O
5J0P
5J0Q
5J0R
5J0S
5J0T
5J0U
5J0W
5J0X
5J0Y
5J29
5J2A
5J2B
5J2C
5J2D
5J2E
5J2F
5J2G
5J2H
5J2I
5J2J
5J2K
5TB8
5TB9
5TBA
5TBB
5TBC
5TZV
5U2R
5U2S
5U2T
5U8G
5U8H
5U8I
5U9H
5UGN
5UGO
5UGP
5V1F
5V1G
5V1H
5V1I
5V1J
5V1N
5V1O
5V1P
5V1R
5VEZ
5VRW
5VRX
5VRY
5VRZ
5VS0
5VS1
5VS2
5VS3
5VS4
5WNX
5WNY
5WNZ
5WO0
6BEL
6BEM
6BTE
6BTF
6CLY
6CPQ
6CR3
6CR4
6CR5
6CR6
6CR7
6CR8
6CR9
6CRB
6CRC
6CRH
6CTI
6CTJ
6CTK
6CTL
6CTM
6CTN
6CTO
6CTP
6CTQ
6CTR
6CTT
6CTU
6CTV
6CTW
6CTX
6CU9
6CUA
6CUB
6DIA
6DIC
6E3R
6E3V
6E3W
6E3X
6G2Q
6MR7
6MR8
6N2R
6N2S
6N2T
6NKR
6NKS
6NKT
6NKU
6NKV
6NKW
6NKX
6NKY
6NKZ
6NL0
6PH5
6PH6
6PKZ
6U2O
6U6B
6UOK
6UOL
6UOM
6W2M
7ICE
7ICF
7ICG
7ICH
7ICI
7ICJ
7ICK
7ICL
7ICM
7ICN
7ICO
7ICP
7ICQ
7ICR
7ICS
7ICT
7ICU
7ICV
8ICA
8ICB
8ICC
8ICE
8ICF
8ICG
8ICH
8ICI
8ICJ
8ICK
8ICL
8ICM
8ICN
8ICO
8ICP
8ICQ
8ICR
8ICS
8ICT
8ICU
8ICV
8ICW
8ICX
8ICY
8ICZ
9ICA
9ICB
9ICC
9ICE
9ICF
9ICG
9ICH
9ICI
9ICJ
9ICK
9ICL
9ICM
9ICN
9ICO
9ICP
9ICQ
9ICR
9ICS
9ICT
9ICU
9ICV
9ICW
9ICX
9ICY
Enriched GO Terms of Interacting Partners
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