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CENPX and NKX3-1
Data Source:
BioGRID
(two hybrid)
CENPX
NKX3-1
Description
centromere protein X
NK3 homeobox 1
Image
GO Annotations
Cellular Component
Condensed Chromosome Kinetochore
Nucleoplasm
Fanconi Anaemia Nuclear Complex
FANCM-MHF Complex
Chromatin
Nucleus
Nucleoplasm
Cytosol
Site Of DNA Damage
Molecular Function
DNA Binding
Double-stranded DNA Binding
Protein Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Estrogen Receptor Activity
Estrogen Receptor Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Protein Self-association
MADS Box Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Resolution Of Meiotic Recombination Intermediates
Replication Fork Processing
Positive Regulation Of Protein Ubiquitination
CENP-A Containing Nucleosome Assembly
Interstrand Cross-link Repair
Cell Division
Kinetochore Assembly
Metanephros Development
Somitogenesis
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Multicellular Organism Development
Salivary Gland Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Male Gonad Development
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell Death
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cell Differentiation
Androgen Receptor Signaling Pathway
Regulation Of Protein Localization
Response To Testosterone
Cellular Response To Drug
Dorsal Aorta Development
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Protein Kinase B Signaling
Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Epithelial Cell Proliferation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Cell Division
Pharyngeal System Development
Branching Involved In Prostate Gland Morphogenesis
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Hypoxia
Mitotic Cell Cycle Arrest
Negative Regulation Of Estrogen Receptor Binding
Positive Regulation Of Androgen Secretion
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Deposition of new CENPA-containing nucleosomes at the centromere
Fanconi Anemia Pathway
Drugs
Diseases
Prostate cancer
GWAS
Birth weight (
31043758
)
Mean corpuscular hemoglobin (
29403010
)
Mean corpuscular hemoglobin concentration (
29403010
)
Prostate cancer (
32986714
26443449
)
Prostate-specific antigen levels (
28139693
)
Waist-hip ratio (
25673412
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
7 interacting genes:
CENPS
FANCM
NKX3-1
REL
TP53
TRIM54
UBE2I
37 interacting genes:
AEN
CCT7
CD200R1L
CENPX
CHPF
CKAP4
FEM1B
HIPK2
HMG20B
HNRNPA0
HSP90B1
LMCD1
MAN2B1
MNAT1
MT-ND4
PEBP1
PTMS
RABL6
RARG
RHOXF2
RNF4
RPL37A
RPSA
SLC22A18
SP1
SP2
SP3
SP4
SP5
SPDEF
SRF
STMN3
TEX264
TOPORS
TPT1
WDR77
ZNF417
Entrez ID
201254
4824
HPRD ID
18121
03620
Ensembl ID
ENSG00000169689
ENSG00000167034
Uniprot IDs
A8MT69
J3QRS1
Q99801
PDB IDs
4DRA
4DRB
4E44
4E45
4NDY
4NE1
4NE3
4NE5
4NE6
2L9R
Enriched GO Terms of Interacting Partners
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