MARK2 and MAP3K3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		MARK2	MAP3K3
Description		microtubule affinity regulating kinase 2	mitogen-activated protein kinase kinase kinase 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle	Cytosol
	Molecular Function	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding	MAPK Cascade Activation Of MAPKK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence
Pathways			Interleukin-1 signaling
Drugs		Fostamatinib	Fostamatinib
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)	Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951)
Interacting Genes		32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ	42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16
Entrez ID		2011	4215
HPRD ID		02753	03965
Ensembl ID		ENSG00000072518	ENSG00000198909
Uniprot IDs		A0A140VJP1 A8K2S4 Q7KZI7	J3KRN4 Q96HN9 Q99759
PDB IDs		3IEC 5EAK 5KZ7 5KZ8	2C60 2JRH 2O2V 2PPH 4Y5O 4YL6
Enriched GO Terms of Interacting Partners?
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