TXLNA and NSMCE2

Data Source:
BioGRID (two hybrid, two hybrid)

		TXLNA	NSMCE2
Description		taxilin alpha	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body PML Body Smc5-Smc6 Complex
	Molecular Function	Protein Binding Syntaxin Binding	Protein Binding Zinc Ion Binding SUMO Transferase Activity SUMO Ligase Activity
	Biological Process	Exocytosis Cytokine-mediated Signaling Pathway B Cell Activation	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Protein Sumoylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Cellular Senescence
Pathways		Other interleukin signaling	SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) C-reactive protein levels ( 30388399) Diffusing capacity of carbon monoxide ( 30694715) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fractures (paediatric) ( 32742401) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Pursuit maintenance gain ( 29064472) Response to statin therapy ( 20339536) Triglyceride levels ( 32203549) White blood cell count ( 32888494)
Interacting Genes		95 interacting genes: AXIN2 AZI2 BIN3 BRCA1 BRMS1L BTF3 BTF3L4 CBY2 CCDC112 CCDC136 CCDC146 CCDC196 CCDC33 CCDC57 CCHCR1 CDC5L CDR2 CEP44 CEP57 CEP57L1 CEP63 CFAP53 DEUP1 DMAP1 DTNB EIF4ENIF1 EPN2 FAM81A FAM9A GAS8 GOLGA2 GOLGA6A GORASP2 HAUS3 HYPK IKBKG KANK2 KIAA1328 KRT13 KRT15 KRT20 KRT24 KRT27 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 KRT75 LCA5 LZTS1 MBIP MCC MED4 MEOX1 MEOX2 MIS18A NACA NDC80 NKAPD1 NMI NSMCE2 NUP62 OLIG2 PIAS2 PPFIA1 PPP1R13B PRDM16 PRPF3 RASSF8 RCOR3 RINT1 SIKE1 SMARCE1 SNF8 SORBS3 SREK1 STMN2 STX1A STX1B STX3 STX4 TBC1D1 TCL1A TFIP11 TNIP1 TP53BP2 TTC33 TXLNB USHBP1 UTP14C VPS52 WASHC1 WASHC3	4 interacting genes: ETV1 TSNAX TXLNA USP28
Entrez ID		200081	286053
HPRD ID		09408	08131
Ensembl ID		ENSG00000084652	ENSG00000156831
Uniprot IDs		P40222	A0A024R9J6 E5RFJ1 Q96MF7
PDB IDs			2YU4
Enriched GO Terms of Interacting Partners?
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