EIF4A2 and PDCD4

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		EIF4A2	PDCD4
Description		eukaryotic translation initiation factor 4A2	programmed cell death 4
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GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 4F Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding RNA Helicase Activity Translation Initiation Factor Activity Helicase Activity Protein Binding ATP Binding ATPase Activity	RNA Binding Protein Binding
	Biological Process	Cytoplasmic Translational Initiation Translational Initiation Regulation Of Translational Initiation Viral Process Negative Regulation Of RNA-directed 5'-3' RNA Polymerase Activity Cellular Response To Leukemia Inhibitory Factor	Apoptotic Process Cell Aging BMP Signaling Pathway Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Inflammatory Response Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Cellular Response To Lipopolysaccharide Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
GWAS			Fish- and plant-related diet ( 32066663)
Interacting Genes		23 interacting genes: BRCA1 CLNS1A DPPA4 ECT2 EIF4G1 EIF4G2 GOLGA2 HSPB2 IPO11 LINC01554 MCPH1 MDFI NEK2 PDCD4 PFDN1 PIH1D2 SLC16A9 SSX2IP SUMO2 TK1 TRIM36 TRIM39 ZNF620	16 interacting genes: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 IBTK LRRK1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1 SKP2 SUMO2
Entrez ID		1974	27250
HPRD ID		03062	10549
Ensembl ID		ENSG00000156976	ENSG00000150593
Uniprot IDs		Q14240	B4DKX4 Q53EL6
PDB IDs		3BOR	2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?
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