AHSG and RRAS2

Data Source:
HPRD (in vitro)

		AHSG	RRAS2
Description		alpha 2-HS glycoprotein	RAS related 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Golgi Membrane Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Kinase Inhibitor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Skeletal System Development Platelet Degranulation Pinocytosis Acute-phase Response Negative Regulation Of Endopeptidase Activity Regulation Of Bone Mineralization Negative Regulation Of Bone Mineralization Negative Regulation Of Kinase Activity Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269)	Alzheimer's disease (cognitive decline) ( 23535033) Apolipoprotein A1 levels ( 32203549) Brain morphology (MOSTest) ( 32665545) Height ( 31562340) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Refractive error ( 32231278) Vitamin D levels ( 25208829)
Interacting Genes		8 interacting genes: CDC42 DCN FBXO2 FBXW7 GRB2 INSR RRAS2 VKORC1	32 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB HDAC7 LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAP1GDS1 RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RGL3 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6
Entrez ID		197	22800
HPRD ID		00727	02518
Ensembl ID		ENSG00000145192	ENSG00000133818
Uniprot IDs		P02765	P62070
PDB IDs			2ERY
Enriched GO Terms of Interacting Partners?
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