PLPP4 and GJA1

Data Source:
BioGRID (two hybrid)

		PLPP4	GJA1
Description		phospholipid phosphatase 4	gap junction protein alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Golgi Membrane Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Early Endosome Multivesicular Body Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Fascia Adherens Gap Junction Connexin Complex Focal Adhesion Intercalated Disc Apical Plasma Membrane Cell Junction Golgi-associated Vesicle Membrane Intracellular Membrane-bounded Organelle Cell-cell Contact Zone Membrane Raft Tight Junction
	Molecular Function	Diacylglycerol Diphosphate Phosphatase Activity Protein Binding Phosphatidate Phosphatase Activity Identical Protein Binding	Gap Junction Channel Activity Protein Binding Beta-catenin Binding Ion Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Tubulin Binding SH3 Domain Binding PDZ Domain Binding Glutathione Transmembrane Transporter Activity Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Disordered Domain Specific Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Blastocyst Hatching Phospholipid Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phospholipid Dephosphorylation Regulation Of Calcium Ion Import	Establishment Of Mitotic Spindle Orientation Negative Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Response To Ischemia Positive Regulation Of Glomerular Filtration Endothelium Development Apoptotic Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Spermatogenesis Heart Development Response To PH Response To Glucose Vascular Transport Positive Regulation Of Gene Expression Cell Communication By Electrical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Glutamate Secretion ATP Transport Gap Junction Assembly Regulation Of Transmembrane Transporter Activity Negative Regulation Of Cell Growth Positive Regulation Of Insulin Secretion Negative Regulation Of Gonadotropin Secretion Response To Estradiol Response To Lipopolysaccharide Response To Retinoic Acid Ion Transmembrane Transport Response To Fluid Shear Stress Cellular Protein Localization Glutathione Transmembrane Transport Maintenance Of Protein Localization In Endoplasmic Reticulum Maintenance Of Blood-brain Barrier Xenobiotic Transport Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Peptide Hormone Positive Regulation Of Protein Catabolic Process Positive Regulation Of Vasoconstriction Decidualization Bone Remodeling Neuron Projection Morphogenesis Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Cell Proliferation Bone Development Negative Regulation Of Wound Healing Cellular Response To Mechanical Stimulus Cellular Response To Parathyroid Hormone Stimulus Atrial Cardiac Muscle Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Cold-induced Thermogenesis Export Across Plasma Membrane Negative Regulation Of Trophoblast Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Mesodermal Cell Differentiation Epididymis Development Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Stem Cell Proliferation Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Behavioral Fear Response
Pathways		Role of phospholipids in phagocytosis	Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction assembly Gap junction degradation Regulation of gap junction activity Regulation of gap junction activity Formation of annular gap junctions
Drugs			Carvedilol
Diseases			Syndactyly Deafness, autosomal recessive Oculodentodigital dysplasia
GWAS			Atrial fibrillation ( 28416818 28416822 29892015) Disease progression in age-related macular degeneration ( 29346644) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Focal epilepsy (with hippocampal sclerosis) ( 30531953) General risk tolerance (MTAG) ( 30643258) HDL cholesterol levels ( 32203549) Heart rate ( 23583979) Heel bone mineral density ( 30598549) Migraine ( 27322543) Peak creatinine levels in vancomycin therapy ( 26030142) PR interval ( 32439900) Protein quantitative trait loci ( 18464913) Pulse pressure ( 28135244 27841878) Resting heart rate ( 29769521 23183192 27798624 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Tendinopathy ( 31615970) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		33 interacting genes: ANKRD46 ARL13B BCL2L13 BIK BMP10 CD74 CISD2 CPLX4 CREB3L1 CYB5B ERGIC3 EVI2A FAM209A FRMD3 GET1 GJA1 GJB5 GPX8 LMNA LRRC59 MGST3 PAGE1 PDZK1IP1 PSCA SGPL1 SLC35A1 SSMEM1 STX1A STX2 SYT2 TMEM139 TMEM45B UPK1B	26 interacting genes: AKT1 CAV1 CCN3 CNST CREB3 CSK CSNK1D GJA3 GJA5 HTR2C MAPK1 MAPK3 MAPK7 NINJ2 PLPP4 PRKCA PRKCB PRKCE PRKCG S100A1 SGSM3 SRC TJP1 TMEM128 TMEM86B UBQLN4
Entrez ID		196051	2697
HPRD ID		18745	00414
Ensembl ID		ENSG00000203805	ENSG00000152661
Uniprot IDs		B7Z3R3 Q5VZY2	A0A654IBU3 P17302
PDB IDs			2LL2
Enriched GO Terms of Interacting Partners?
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