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PHC2 and THAP7
Data Source:
BioGRID
(two hybrid)
PHC2
THAP7
Description
polyhomeotic homolog 2
THAP domain containing 7
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Nucleus
Nucleoplasm
Chromosome
Nuclear Speck
Nuclear Membrane
Intracellular Membrane-bounded Organelle
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
RNA Polymerase II Transcription Corepressor Binding
DNA Binding
Protein Binding
Nucleosomal Histone Binding
Methylated Histone Binding
Identical Protein Binding
Histone Deacetylase Binding
Metal Ion Binding
Protein N-terminus Binding
Lysine-acetylated Histone Binding
C2H2 Zinc Finger Domain Binding
Phosphorylated Histone Binding
General Transcription Initiation Factor Binding
Biological Process
Multicellular Organism Development
Spermatogenesis
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Negative Regulation Of Histone Acetylation
Negative Regulation Of Transcription, DNA-templated
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Drugs
Diseases
GWAS
Adventurousness (
30643258
)
Blood urea nitrogen levels (
31152163
29403010
)
General risk tolerance (MTAG) (
30643258
)
Pulse pressure (
30224653
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
)
Interacting Genes
79 interacting genes:
AEN
AFG3L2
AP1M1
BMI1
BSDC1
BYSL
C1orf109
CARD9
CBX2
CRK
CRKL
CSNK2B
DRG1
ENKD1
FAM124A
FAM13C
FAM161A
FAM74A1
FAM74A4
FHL3
FOSB
GFI1B
GRB2
H3-4
HDAC7
KAT5
KBTBD7
KDM1A
KIFC3
KLHDC7B
KRT31
L3MBTL3
LMO1
LMO2
LMO3
MAB21L3
MAGEB6
MAPK14
MAPK6
MAPKAPK2
MCM2
MCRS1
MFAP1
MLLT6
MORF4L2
NCK1
PCGF2
PCGF3
PCGF5
PHC1
PLAGL2
PLK1
POLR2L
PPP1R16B
PRKAA1
PRPF3
PRPF31
RBM39
RNF2
RPL7
RWDD2B
SCMH1
SDCBP
SFMBT1
SIAH1
SMAD3
SPATC1L
SSX2IP
SYT16
TAB1
THAP7
TMEM70
TRIM41
TRIM55
TRIM63
ZBTB24
ZGPAT
ZMAT2
ZNF417
63 interacting genes:
ANKRD28
APP
CCDC136
CCDC85B
CCNDBP1
CDC37
CYSRT1
DESI2
DVL3
EFEMP2
EHMT2
FBXO7
FHL3
FSD2
GABARAPL1
GNAI1
GOLGA2
GOLGA6L9
H3C1
H4C1
HCFC1
HDAC3
HOXA1
KRT27
KRT31
KRT34
KRT40
KRTAP1-3
KRTAP10-3
KRTAP10-8
KRTAP17-1
KRTAP4-12
LDOC1
LNX1
LURAP1
LZTS2
MAGOHB
MAP1LC3B
MCC
MDFI
MID2
MTUS2
NBPF19
NOTCH2NLA
NTAQ1
PELI2
PHC2
PHF19
PICK1
PIN1
PNMA2
PPP3CC
SET
TAF1B
TFIP11
THAP11
TLE5
TPM3
TRAF1
TRAF2
TRAF5
ZDHHC17
ZRANB1
Entrez ID
1912
80764
HPRD ID
10340
15500
Ensembl ID
ENSG00000134686
ENSG00000184436
Uniprot IDs
A0A0A0MSI2
Q8IXK0
Q9BT49
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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