AHCY and APPBP2

Data Source:
BioGRID (two hybrid)

		AHCY	APPBP2
Description		adenosylhomocysteinase	amyloid beta precursor protein binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Melanosome Neuron Projection Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	Adenosylhomocysteinase Activity Protein Binding Adenyl Nucleotide Binding Identical Protein Binding NAD Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Sulfur Amino Acid Metabolic Process Response To Hypoxia Chronic Inflammatory Response To Antigenic Stimulus One-carbon Metabolic Process Response To Nutrient S-adenosylhomocysteine Catabolic Process Methylation S-adenosylmethionine Cycle Circadian Sleep/wake Cycle	Intracellular Protein Transport Intracellular Transport
Pathways		Methylation Sulfur amino acid metabolism Metabolism of ingested SeMet, Sec, MeSec into H2Se Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)
Drugs		(1'R,2'S)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-yl)Adenine 3'-Oxo-Adenosine D-Eritadenine Copper
Diseases		Hypermethioninemia; Methionine adenosyltransferase deficiency; S-adenosylhomocysteine hydrolase deficiency
GWAS		Fish- and plant-related diet ( 32066663) Heel bone mineral density ( 30598549) Height ( 28552196) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Vitiligo ( 27723757)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		7 interacting genes: ANKRD40 APPBP2 C1orf50 POT1 PXN TERF1 YWHAQ	120 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ATP13A1 BCL7A BIN2 C1orf50 C6orf226 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MFSD3 MGAT4B MLLT3 MMP28 MSH2 MSLN MUL1 MYLK NFYA NPRL3 PCSK5 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC7A10 SLC9A3R1 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		191	10513
HPRD ID		01621	05616
Ensembl ID		ENSG00000101444	ENSG00000062725
Uniprot IDs		A0A384MTQ3 P23526 Q1RMG2	A0A024QZ47 Q92624
PDB IDs		1A7A 1LI4 3NJ4 4PFJ 4PGF 4YVF 5W49 5W4B
Enriched GO Terms of Interacting Partners?
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