EDA and OSTC

Data Source:
BioGRID (two hybrid)

		EDA	OSTC
Description		ectodysplasin A	oligosaccharyltransferase complex non-catalytic subunit
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GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Membrane Lipid Droplet Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell	Oligosaccharyltransferase Complex Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Death Receptor Agonist Activity Receptor Ligand Activity	Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Immune Response Cell-matrix Adhesion Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Animal Organ Development Positive Regulation Of NF-kappaB Transcription Factor Activity Salivary Gland Cavitation Hair Follicle Placode Formation Trachea Gland Development Positive Regulation Of Canonical Wnt Signaling Pathway	Protein N-linked Glycosylation Via Asparagine
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic Tooth agenesis; Hypodontia
GWAS		Male-pattern baldness ( 30573740) Metabolite levels ( 23823483) Monobrow ( 27182965) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Tooth agenesis (maxillary lateral incisors) ( 29364747)
Interacting Genes		24 interacting genes: ATP6V0C CTXN3 CYB561 DOLK EDA2R EDAR EMP1 EMP3 FURIN GIMAP5 LEPROTL1 LPAR3 MAL MS4A13 NIPAL3 OSTC OSTCP1 PLN PMP22 SEC22A SLC38A7 TMEM42 TMEM50B TMEM60	6 interacting genes: ATP13A2 CCR9 EDA F2RL1 GPR35 TRARG1
Entrez ID		1896	58505
HPRD ID		02347	13120
Ensembl ID		ENSG00000158813	ENSG00000198856
Uniprot IDs		A0A0U5J797 Q92838	A0A024RDJ1 A0A087WUD3 Q9NRP0
PDB IDs		1RJ7 1RJ8	6S7O
Enriched GO Terms of Interacting Partners?
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