EBF1 and ZNF521

Data Source:
HPRD (in vitro)

		EBF1	ZNF521
Description		EBF transcription factor 1	zinc finger protein 521
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Protein Dimerization Activity C2H2 Zinc Finger Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment
Pathways		Transcriptional regulation of white adipocyte differentiation	RUNX2 regulates osteoblast differentiation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Anorexia nervosa (excluding migration to or from binge-eating disorder or bulimia nervosa) ( 28630421) Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758 27680694) Blood pressure ( 21909110) Blood protein levels ( 29875488) Body size at age 10 ( 32376654) Breast cancer ( 29059683 23535729 23535733) Carotid intima media thickness ( 26343869) Cognitive decline rate in late mild cognitive impairment ( 26252872) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 28135244 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General risk tolerance (MTAG) ( 30643258) Gestational age at birth (maternal effect) ( 28877031) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Hip circumference (psychosocial stress interaction) ( 25271088) Hypertension ( 21909115 30487518) Hypospadias ( 25108383) Inflammatory skin disease ( 25574825) Longevity (85 years and older) ( 24688116) Longevity (90 years and older) ( 24688116) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Male-pattern baldness ( 29146897 27182965 28196072) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pericardial adipose tissue adjusted for height and weight ( 27918534) Pericardial fat ( 27918534) Platelet count ( 32888494) Post bronchodilator FEV1 ( 26634245) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30224653 28135244 27841878 28739976 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 26390057 28135244 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes (adjusted for BMI) ( 30297969)	Adverse response to lamotrigine and phenytoin ( 22379998) Chronotype ( 30696823) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Height ( 31562340) High density lipoprotein cholesterol levels ( 30498476) Mitochondrial DNA levels ( 25240745) Myeloproliferative neoplasms ( 33057200) Nickel levels ( 26025379) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Systemic juvenile idiopathic arthritis ( 27927641) Takayasu arteritis ( 25604533) Toenail selenium levels ( 25343990) Urgency urinary incontinence ( 25524241)
Interacting Genes		9 interacting genes: ATPAF2 CREBBP ERO1A HOMEZ MTNR1B PAX5 POU6F2 ZNF423 ZNF521	8 interacting genes: BRAP EBF1 EIF1AD GATA1 LYST RARS1 SMAD1 SMAD4
Entrez ID		1879	25925
HPRD ID		01256	18350
Ensembl ID		ENSG00000164330	ENSG00000198795
Uniprot IDs		B4E2U8 Q9UH73	J3KTI4 Q8IYZ2 Q96K83
PDB IDs		3LYR 3MQI
Enriched GO Terms of Interacting Partners?
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