TSC22D3 and MTA2

Data Source:
BioGRID (two hybrid)

		TSC22D3	MTA2
Description		TSC22 domain family member 3	metastasis associated 1 family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Ion Transmembrane Transport Negative Regulation Of Activation-induced Cell Death Of T Cells	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Stimuli-sensing channels	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: BRME1 DCLK2 FOS HPCAL4 JUN MAD1L1 MTA2 NFKB1 NFKB2 PLEKHF2 RAF1 REL RELA SUMO1	23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1
Entrez ID		1831	9219
HPRD ID		04266	07233
Ensembl ID		ENSG00000157514	ENSG00000149480
Uniprot IDs		Q5JRJ2 Q99576	A0A024R534 O94776
PDB IDs
Enriched GO Terms of Interacting Partners?
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