RCAN1 and MAP3K3

Data Source:
HPRD (in vivo)

		RCAN1	MAP3K3
Description		regulator of calcineurin 1	mitogen-activated protein kinase kinase kinase 3
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytosol
	Molecular Function	Nucleic Acid Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Calcium-mediated Signaling Calcineurin-NFAT Signaling Cascade Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade	MAPK Cascade Activation Of MAPKK Activity Blood Vessel Development Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Autophosphorylation Interleukin-1-mediated Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Cellular Senescence
Pathways			Interleukin-1 signaling
Drugs		Dipyridamole	Fostamatinib
Diseases
GWAS		Cancer ( 29299148) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Adult body size ( 32376654) Height ( 21998595 28552196 22021425 25429064 18391951)
Interacting Genes		8 interacting genes: APP BTRC GSK3B MAP3K3 MAPK3 PPP3CA USP22 UXT	42 interacting genes: BIRC2 BRCA1 CDC37 COPS5 EGFR GAB1 GLRX3 GTF2I HSP90AA1 HSP90AB1 HSPA2 IKBKB MAP2K3 MAP2K4 MAP2K5 MAP2K7 MAP3K5 MAP3K7 MARK2 MBP NEDD4 NEDD4L NFKBIA PFDN2 PRKACA RCAN1 RIPK1 SMURF1 SPAG9 TOM1L1 TRAF6 TRAF7 VWF WNK1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZBTB16
Entrez ID		1827	4215
HPRD ID		04226	03965
Ensembl ID		ENSG00000159200	ENSG00000198909
Uniprot IDs		B7Z1F0 E9PDJ2 P53805 Q6FGP2 Q6ZMM3 V9GYW9	J3KRN4 Q96HN9 Q99759
PDB IDs		6UUQ	2C60 2JRH 2O2V 2PPH 4Y5O 4YL6
Enriched GO Terms of Interacting Partners?
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