DRD3 and EPB41

Data Source:
HPRD (in vivo, in vitro)

		DRD3	EPB41
Description		dopamine receptor D3	erythrocyte membrane protein band 4.1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Endocytic Vesicle Cell Projection Apical Part Of Cell Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Density Membrane	Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle Cell Cortex Region
	Molecular Function	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Protein Binding Protein Domain Specific Binding D1 Dopamine Receptor Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Protein C-terminus Binding Spectrin Binding Protein N-terminus Binding Phosphoprotein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Synaptic Transmission, Dopaminergic G Protein-coupled Receptor Internalization Cellular Calcium Ion Homeostasis Autophagy G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Learning Or Memory Learning Locomotory Behavior Positive Regulation Of Cell Population Proliferation Visual Learning Regulation Of Dopamine Secretion Negative Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Cytokinesis Circadian Regulation Of Gene Expression Response To Histamine Social Behavior Gastric Emptying Positive Regulation Of Renal Sodium Excretion Response To Cocaine Dopamine Metabolic Process Response To Drug Negative Regulation Of Apoptotic Process Regulation Of Potassium Ion Transport Response To Morphine Regulation Of Circadian Sleep/wake Cycle, Sleep Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Acid Secretion Behavioral Response To Cocaine Negative Regulation Of Oligodendrocyte Differentiation Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Musculoskeletal Movement, Spinal Reflex Action Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Positive Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity	Cell Cycle Regulation Of Cell Shape Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Protein Binding Cell Division Regulation Of Calcium Ion Transport Protein-containing Complex Assembly Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex
Pathways		Dopamine receptors G alpha (i) signalling events	Neurexins and neuroligins
Drugs		Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Sulpiride Loxapine Remoxipride Pramipexole Chlorpromazine Buspirone Haloperidol Amoxapine Lisuride Apomorphine Dopamine Ergoloid mesylate Pimozide Domperidone Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Yohimbine Methotrimeprazine Iloperidone Rotigotine ACP-104 Cariprazine Mianserin Asenapine Amisulpride Sarizotan Sumanirole Captodiame AS-8112 Blonanserin Pipamperone Tianeptine Dihydro-alpha-ergocryptine Epicriptine Pardoprunox Piribedil Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases			Hereditary elliptocytosis (HE)
GWAS		Chronotype ( 30696823) Feeling hurt ( 29500382) Personality dimensions ( 23903073) Smooth-surface caries ( 24556642)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		16 interacting genes: CLIC6 DRD1 EEF1B2 EEF1G EPB41 EPB41L1 EPB41L2 FLNA GIPC1 GNAI1 GRB2 MPDZ NCK1 NCS1 RDX USP48	39 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10
Entrez ID		1814	2035
HPRD ID		00540	00558
Ensembl ID		ENSG00000151577	ENSG00000159023
Uniprot IDs		A1A4V4 A8K8E4 E9PCM4 P35462 X5D2G4	A0A2R8Y7Y3 P11171 Q1WWM3 Q29RX4 Q59F12
PDB IDs		3PBL	1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?
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