DMD and DTNA

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DMD	DTNA
Description		dystrophin	dystrobrevin alpha
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Cell Surface Dystrophin-associated Glycoprotein Complex Syntrophin Complex Lateral Plasma Membrane Z Disc Cell-substrate Junction Filopodium Filopodium Membrane Protein-containing Complex Sarcolemma Costamere Neuron Projection Terminus Membrane Raft Synapse Postsynaptic Membrane	Nucleoplasm Cytoplasm Plasma Membrane Cell Junction Protein-containing Complex Intermediate Filament Cytoskeleton Synapse
	Molecular Function	Dystroglycan Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Zinc Ion Binding Structural Constituent Of Muscle Myosin Binding Vinculin Binding Nitric-oxide Synthase Binding	Protein Binding Zinc Ion Binding
	Biological Process	Regulation Of Heart Rate Cytoskeleton Organization Muscle Organ Development Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction Muscle Filament Sliding Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Protein Localization Cellular Protein-containing Complex Assembly Maintenance Of Blood-brain Barrier Response To Muscle Stretch Peptide Biosynthetic Process Muscle Cell Cellular Homeostasis Muscle Fiber Development Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Cell Action Potential Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	Striated Muscle Contraction Signal Transduction Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Synaptic Signaling
Pathways		Non-integrin membrane-ECM interactions Striated Muscle Contraction
Drugs		Golodirsen
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD) Dystrophinopathies, including: Duchenne muscular dystrophy (DMD); Becker muscular dystrophy (BMD); X-linked dilated cardiomyopathy (XLCM) Dilated cardiomyopathy (DCM)
GWAS		Ankle-brachial index ( 31388106) Anxiety in major depressive disorder ( 24047446) Body mass index ( 28892062) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mild influenza (H1N1) infection ( 26379185) Response to anti-depressant treatment in major depressive disorder ( 22041458) Temporomandibular joint disorder ( 28081371) Waist circumference ( 28552196)	Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) PR interval ( 32439900) Urate levels in overweight individuals ( 25811787)
Interacting Genes		29 interacting genes: ACTA1 ACTC1 APP CADPS CADPS2 CDC25A CTNNAL1 DAG1 DGKZ DISC1 DTNA DTNB FASLG HAUS1 HNF4A KCNJ12 KRT19 KRT8 MAP3K5 PGM5 PICK1 SGCZ SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 TRAF3IP1 UTRN	17 interacting genes: ACTA1 APPL1 DMD DRP2 DTNBP1 GFI1B HMG20A KCNJ12 SNTA1 SNTB1 SNTB2 SNTG1 SNTG2 STAT3 SYNC SYNM UTRN
Entrez ID		1756	1837
HPRD ID		02303	03141
Ensembl ID		ENSG00000198947	ENSG00000134769
Uniprot IDs		A0A0S2Z3B5 A0A0S2Z3J7 A7E212 P11532 Q16484 Q4G0X0	A0A024RC32 B7Z3X3 Q9Y4J8
PDB IDs		1DXX 1EG3 1EG4 3UUN	2E5R
Enriched GO Terms of Interacting Partners?
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