DIO2 and USP33

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DIO2	USP33
Description		iodothyronine deiodinase 2	ubiquitin specific peptidase 33
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Focal Adhesion VCB Complex Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Thyroxine 5'-deiodinase Activity Selenium Binding Ubiquitin Protein Ligase Binding Thyroxine 5-deiodinase Activity	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Small GTPase Binding Ubiquitin Binding
	Biological Process	Selenocysteine Incorporation Thyroid Hormone Generation Thyroid Hormone Metabolic Process Thyroid Hormone Catabolic Process Hormone Biosynthetic Process Brown Fat Cell Differentiation Positive Regulation Of Cold-induced Thermogenesis	Ubiquitin-dependent Protein Catabolic Process Endocytosis Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To Starvation Regulation Of Autophagy Cell Migration Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Protein Binding Positive Regulation Of Protein Binding Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Regulation of thyroid hormone activity	Ub-specific processing proteases Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Free thyroxine concentration ( 30367059) Metabolite levels ( 23823483) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Rosacea symptom severity ( 29771307)	Adult body size ( 32376654) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		6 interacting genes: MARCHF6 UBE2G1 UBE2J1 USP20 USP33 WSB1	14 interacting genes: CCP110 CHRM5 DDX56 DIO2 EIF6 ELOC SELENBP1 TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL
Entrez ID		1734	23032
HPRD ID		09027	10297
Ensembl ID		ENSG00000211448	ENSG00000077254
Uniprot IDs		A8K845 Q92813	Q8TEY7
PDB IDs			2UZG
Enriched GO Terms of Interacting Partners?
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