DEFB4A and CCR6

Data Source:
HPRD (in vivo, in vitro)

		DEFB4A	CCR6
Description		defensin beta 4A	C-C motif chemokine receptor 6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane
	Molecular Function	Protein Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Antimicrobial Humoral Response Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Epithelial Cell Migration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Beta defensins Defensins	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS			Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 18587394 28067908 20570966 21102463 23850713) Graves' disease ( 22922229) Inflammatory bowel disease ( 27569725 28067908 23128233) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 20526339 27723757)
Interacting Genes		3 interacting genes: CCR6 KCNA3 TLR4	5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1
Entrez ID		1673	1235
HPRD ID		03739	03498
Ensembl ID		ENSG00000171711	ENSG00000112486
Uniprot IDs		O15263	P51684
PDB IDs		1E4Q 1FD3 1FD4 1FQQ 6CS9	6WWZ
Enriched GO Terms of Interacting Partners?
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