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DEFA1 and C1QB
Data Source:
HPRD
(in vitro)
DEFA1
C1QB
Description
defensin alpha 1
complement C1q B chain
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Golgi Lumen
Azurophil Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Synapse
Collagen-containing Extracellular Matrix
Blood Microparticle
Postsynapse
Molecular Function
Protein Binding
Protein Binding
Biological Process
Innate Immune Response In Mucosa
Chemotaxis
Immune Response
T Cell Chemotaxis
Antimicrobial Humoral Response
Antibacterial Humoral Response
Intracellular Estrogen Receptor Signaling Pathway
Killing Of Cells Of Other Organism
Defense Response To Protozoan
Neutrophil Degranulation
Pore Formation In Membrane Of Other Organism During Symbiotic Interaction
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Defense Response To Fungus
Defense Response To Virus
Membrane Disruption In Other Organism
Killing By Host Of Symbiont Cells
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cellular Response To Lipopolysaccharide
Complement Activation
Complement Activation, Classical Pathway
Regulation Of Complement Activation
Innate Immune Response
Synapse Pruning
Pathways
Defensins
Alpha-defensins
Neutrophil degranulation
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Drugs
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Basophil percentage of white cells (
32888494
)
Blood protein levels (
30072576
)
Chromium levels (
26025379
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Endometriosis (
28333195
)
Periodontitis (PAL4Q3) (
24024966
)
Interacting Genes
6 interacting genes:
C1QB
DEFA3
GSK3B
PFDN1
SERPINF2
UBQLN2
11 interacting genes:
C1QA
C1QC
C1R
DEFA1
EDA2R
HRG
IL32
MYOC
PTX3
RELA
UBQLN2
Entrez ID
1667
713
HPRD ID
00499
00394
Ensembl ID
ENSG00000206047
ENSG00000173369
Uniprot IDs
P59665
A0A024RAB9
P02746
PDB IDs
2KHT
2PM1
3GNY
3H6C
3HJ2
3HJD
3LO1
3LO2
3LO4
3LO6
3LO9
3LOE
3LVX
4DU0
4LB1
4LB7
4LBB
4LBF
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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