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DDIT3 and HSD17B14
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
DDIT3
HSD17B14
Description
DNA damage inducible transcript 3
hydroxysteroid 17-beta dehydrogenase 14
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Late Endosome
Cytosol
Protein-DNA Complex
CHOP-C/EBP Complex
CHOP-ATF4 Complex
CHOP-ATF3 Complex
Cytosol
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
CAMP Response Element Binding Protein Binding
Protein Homodimerization Activity
Leucine Zipper Domain Binding
Protein Heterodimerization Activity
Transcription Regulator Inhibitor Activity
Estradiol 17-beta-dehydrogenase Activity
Protein Binding
Identical Protein Binding
Testosterone 17-beta-dehydrogenase (NADP+) Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Blood Vessel Maturation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
ER Overload Response
Response To Unfolded Protein
Cell Cycle Arrest
Sensory Perception Of Sound
Anterior/posterior Axis Specification
Regulation Of Autophagy
Wnt Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-17 Production
Negative Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-8 Production
Negative Regulation Of CREB Transcription Factor Activity
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Response To Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cell Redox Homeostasis
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Release Of Sequestered Calcium Ion Into Cytosol
Negative Regulation Of Protein Kinase B Signaling
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Estrogen Biosynthetic Process
Steroid Catabolic Process
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
ATF6 (ATF6-alpha) activates chaperone genes
FOXO-mediated transcription of cell death genes
FOXO-mediated transcription of cell death genes
Response of EIF2AK4 (GCN2) to amino acid deficiency
Response of EIF2AK1 (HRI) to heme deficiency
Estrogen biosynthesis
Drugs
Diseases
Myxoid liposarcoma
GWAS
Brain morphology (MOSTest) (
32665545
)
Blood protein levels (
30072576
)
Resting metabolic rate (
28476931
)
Interacting Genes
68 interacting genes:
AMOTL2
ATF2
ATF3
ATF4
ATPAF2
BACH1
BACH2
BATF
BATF2
BATF3
CCDC153
CDK6
CEBPA
CEBPB
CEBPE
CEBPG
CRACR2A
CREB3
CREB3L1
CREBL2
CSNK2A1
DBP
DGCR2
DNMT3L
EMSY
EP300
EPAS1
F2
FOS
FOSL1
FOSL2
GIMAP6
GIPC1
GP1BA
HOXA5
HSD17B14
IKBKG
JDP2
JUN
JUNB
JUND
KPNA2
LMO2
LNX1
MAFF
MAFG
MAPK14
MCMBP
NFIL3
PCM1
PICALM
POLR1D
RAI1
RPS3
RPS3A
SNAPC5
SPOP
SRA1
SSX3
TEDC1
TNFSF12
TRIB3
TXN2
TXNDC2
VPS37C
ZBTB25
ZC3H14
ZSCAN31
24 interacting genes:
AKIRIN2
BRIP1
CA8
CDKN2D
CYTOR
DDIT3
INCA1
MIA3
MIR4435-2HG
MPG
NEK6
NTAQ1
NUDT18
OTUD3
PGLYRP3
PHF1
PICK1
PIDD1
PSMA1
REL
SNAPC3
SNRPC
SREK1IP1
TBC1D22B
Entrez ID
1649
51171
HPRD ID
00529
16801
Ensembl ID
ENSG00000175197
ENSG00000087076
Uniprot IDs
P35638
Q53YD1
A0A140VJH8
Q9BPX1
PDB IDs
1YDE
5EN4
5HS6
5ICM
5ICS
5JS6
5JSF
5L7T
5L7W
5L7Y
5O42
5O43
5O6O
5O6X
5O6Z
5O72
5O7C
6EMM
6FFB
6G4L
6GBT
6GTB
6GTU
6H0M
6HNO
6QCK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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