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SPRED1 and BLZF1
Data Source:
BioGRID
(two hybrid)
SPRED1
BLZF1
Description
sprouty related EVH1 domain containing 1
basic leucine zipper nuclear factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
Caveola
Cytoplasmic Vesicle
Golgi Membrane
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Molecular Function
Stem Cell Factor Receptor Binding
Protein Binding
Protein Kinase Binding
Phosphatase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
Biological Process
MAPK Cascade
Inactivation Of MAPK Activity
Negative Regulation Of Protein Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Phosphatase Activity
Negative Regulation Of Angiogenesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of MAPK Cascade
Negative Regulation Of MAPK Cascade
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Vasculogenesis Involved In Coronary Vascular Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Protein Deacetylation
Negative Regulation Of Lens Fiber Cell Differentiation
Golgi Organization
Golgi To Plasma Membrane Protein Transport
Pathways
Regulation of RAS by GAPs
FGFRL1 modulation of FGFR1 signaling
RAS signaling downstream of NF1 loss-of-function variants
Golgi Cisternae Pericentriolar Stack Reorganization
Drugs
Diseases
Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS
Bipolar disorder (
20351715
)
Birth weight (
31043758
)
Cognitive performance (processing speed) (
31598132
)
Crohn's disease (
23128233
)
Erosive tooth wear (severe vs non-severe) (
29898447
)
Erosive tooth wear (severe vs none or mild) (
29898447
)
HDL cholesterol levels x long total sleep time interaction (2df test) (
31719535
)
Hypersomnia (HLA-DQB1*06:02 negative) (
23646285
)
Interacting Genes
37 interacting genes:
ANKS1A
AQP1
BEX2
BLZF1
C2orf68
CCDC185
CDKN1A
CREB5
DNAJB11
FAM118B
FAM90A1
GLYCTK
HEXIM2
HPCAL4
HSF2BP
IL16
KIT
MAB21L3
MEOX2
NAGK
NCALD
OSGEP
PIH1D2
PPP1CA
PPP1R7
PRPF18
RCC1
RIN1
SPG21
SUV39H1
TSC22D1
TTC19
VSNL1
ZNF408
ZNF417
ZNF587
ZNF655
101 interacting genes:
AKAP9
AMOTL2
ANKS1A
AQP1
BAG4
BANP
BCL6
BEX2
CARD9
CCDC120
CCDC33
CCNH
CDC37
CDK18
CFAP206
CHCHD3
CINP
CKS2
CTNNA3
DNMT3L
ENKD1
ERCC3
EWSR1
EXOC8
FAM124B
FAM90A1
FBF1
FHL2
FRMD6
FRS3
GEM
GORASP2
HCLS1
HDAC4
HOXA1
HOXC8
IGFN1
IKZF3
IL16
IQUB
KANK2
KAT5
KCTD9
KDM1A
KIF9
KLHL38
LGALS14
LMO1
LMO2
LMO3
LNX1
MID2
MISP
MKRN3
NTAQ1
OAZ3
PCDHB12
PIK3R3
PKN1
POLR1C
PRKAB2
PRMT6
PRPF18
PSMA1
PTPN11
RAB2A
RAB2B
RAB39A
RANBP3
RHOJ
SCNM1
SMAD3
SMARCB1
SPRED1
SRA1
SSX2
SUV39H2
SYT17
TBC1D22B
TBC1D7
TCAP
TCF19
TEKT4
TNS2
TRAPPC2L
TRIM59
TSC22D4
TSTD2
TTC23
TXNDC5
USHBP1
VPS28
ZBTB16
ZBTB24
ZGPAT
ZMAT1
ZNF124
ZNF410
ZNF688
ZNF76
ZZZ3
Entrez ID
161742
8548
HPRD ID
11601
16367
Ensembl ID
ENSG00000166068
ENSG00000117475
Uniprot IDs
Q7Z699
Q9H2G9
PDB IDs
3SYX
6V65
6V6F
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Intersection)
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