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CYP27B1 and SMC3
Data Source:
BioGRID
(affinity chromatography technology)
CYP27B1
SMC3
Description
cytochrome P450 family 27 subfamily B member 1
structural maintenance of chromosomes 3
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Chromosome, Centromeric Region
Chromatin
Lateral Element
Nucleoplasm
Chromosome
Cytosol
Cohesin Complex
Nuclear Matrix
Meiotic Cohesin Complex
Nuclear Meiotic Cohesin Complex
Mitotic Spindle Pole
Molecular Function
Calcidiol 1-monooxygenase Activity
Iron Ion Binding
Heme Binding
Secalciferol 1-monooxygenase Activity
Chromatin Binding
Microtubule Motor Activity
Protein Binding
ATP Binding
Mediator Complex Binding
Protein Heterodimerization Activity
Beta-tubulin Binding
Dynein Complex Binding
Biological Process
Vitamin Metabolic Process
Calcium Ion Transport
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Calcidiol 1-monooxygenase Activity
Positive Regulation Of Vitamin D 24-hydroxylase Activity
Bone Mineralization
Negative Regulation Of Cell Growth
Regulation Of Bone Mineralization
Response To Lipopolysaccharide
Response To Vitamin D
Response To Interferon-gamma
Calcitriol Biosynthetic Process From Calciol
Vitamin D Metabolic Process
Vitamin D Catabolic Process
Response To Estrogen
Positive Regulation Of Keratinocyte Differentiation
Decidualization
Calcium Ion Homeostasis
G1 To G0 Transition
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Mitotic Cell Cycle
Regulation Of DNA Replication
DNA Repair
Sister Chromatid Cohesion
Stem Cell Population Maintenance
Cell Division
Meiotic Cell Cycle
Mitotic Spindle Assembly
Pathways
Vitamin D (calciferol) metabolism
Vitamins
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Meiotic synapsis
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
Estrogen-dependent gene expression
Drugs
Alfacalcidol
Diseases
Type I diabetes mellitus
Cornelia de Lange syndrome (CdLS)
GWAS
Brain morphology (MOSTest) (
32665545
)
Multiple sclerosis (
19525955
21833088
)
Acute respiratory distress syndrome in sepsis (
31982041
)
Lumbar spine bone mineral density (integral) (
27476799
)
Metabolite levels (
23823483
)
Interacting Genes
18 interacting genes:
APC
CEP63
DISC1
ESCO2
ESR1
FEZ1
FEZ2
KIFAP3
MTNR1B
MXD1
MXD3
MXD4
MXI1
RPGR
SMC1A
SMC1B
SUMO2
TRAF3IP1
Entrez ID
1594
9126
HPRD ID
02031
05829
Ensembl ID
ENSG00000111012
ENSG00000108055
Uniprot IDs
O15528
Q9UQE7
PDB IDs
6WG3
6WG4
6WG6
6WGE
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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