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CYP27B1 and TMEM50B
Data Source:
BioGRID
(biochemical)
CYP27B1
TMEM50B
Description
cytochrome P450 family 27 subfamily B member 1
transmembrane protein 50B
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Golgi Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Calcidiol 1-monooxygenase Activity
Iron Ion Binding
Heme Binding
Secalciferol 1-monooxygenase Activity
Molecular_function
Protein Binding
Biological Process
Vitamin Metabolic Process
Calcium Ion Transport
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Calcidiol 1-monooxygenase Activity
Positive Regulation Of Vitamin D 24-hydroxylase Activity
Bone Mineralization
Negative Regulation Of Cell Growth
Regulation Of Bone Mineralization
Response To Lipopolysaccharide
Response To Vitamin D
Response To Interferon-gamma
Calcitriol Biosynthetic Process From Calciol
Vitamin D Metabolic Process
Vitamin D Catabolic Process
Response To Estrogen
Positive Regulation Of Keratinocyte Differentiation
Decidualization
Calcium Ion Homeostasis
G1 To G0 Transition
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Biological_process
Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway
Pathways
Vitamin D (calciferol) metabolism
Vitamins
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Drugs
Alfacalcidol
Diseases
Type I diabetes mellitus
GWAS
Brain morphology (MOSTest) (
32665545
)
Multiple sclerosis (
19525955
21833088
)
Crohn's disease (
23128233
)
Educational attainment (
25201988
)
Interacting Genes
21 interacting genes:
AMIGO1
BCL2L1
CLRN1
CREB3L1
EDA
FAM209A
FXYD3
GPR152
GPX8
HLA-DPA1
LEPROTL1
LHFPL5
NCR1
SCN3B
SLC10A6
SLC16A13
SLC35C2
TMEM14B
TMEM52B
TMEM88
TMX2
Entrez ID
1594
757
HPRD ID
02031
10747
Ensembl ID
ENSG00000111012
ENSG00000142188
Uniprot IDs
O15528
P56557
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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