CYP27B1 and MYL6

Data Source:
BioGRID (x-ray crystallography, biochemical)
HPRD (in vitro)

		CYP27B1	MYL6
Description		cytochrome P450 family 27 subfamily B member 1	myosin light chain 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane	Cytosol Brush Border Membrane Myosin Complex Unconventional Myosin Complex Vesicle Extracellular Exosome
	Molecular Function	Calcidiol 1-monooxygenase Activity Iron Ion Binding Heme Binding Secalciferol 1-monooxygenase Activity	Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Actin-dependent ATPase Activity
	Biological Process	Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Interferon-gamma Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Catabolic Process Response To Estrogen Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway	Muscle Contraction Skeletal Muscle Tissue Development Muscle Filament Sliding
Pathways		Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs		Alfacalcidol
Diseases		Type I diabetes mellitus
GWAS		Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)	Asthma ( 31619474)
Interacting Genes			7 interacting genes: ADAMTS12 DNAJB9 EWSR1 GLP1R MLH1 MOB4 NUDT21
Entrez ID		1594	4637
HPRD ID		02031	17618
Ensembl ID		ENSG00000111012	ENSG00000092841
Uniprot IDs		O15528	P60660
PDB IDs
Enriched GO Terms of Interacting Partners?
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