ZNF746 and PRKRA

Data Source:
BioGRID (two hybrid)

		ZNF746	PRKRA
Description		zinc finger protein 746	protein activator of interferon induced protein kinase EIF2AK2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Death	Protein Phosphorylation Immune Response Negative Regulation Of Cell Population Proliferation Response To Virus MiRNA Metabolic Process Viral Process Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Skeletal System Morphogenesis Regulation Of Catalytic Activity Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Generic Transcription Pathway	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)	Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)
Interacting Genes		14 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3	28 interacting genes: ADARB1 AGO2 CEBPZ CEP126 COPS6 DICER1 EHHADH EIF2AK2 GDF9 LNX1 LYAR NKRF PIAS2 POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 STAU1 STRBP TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZMAT4 ZNF746
Entrez ID		155061	8575
HPRD ID		08099	04573
Ensembl ID		ENSG00000181220	ENSG00000180228
Uniprot IDs		Q6NUN9	B4DJC7 O75569
PDB IDs			2DIX
Enriched GO Terms of Interacting Partners?
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