CYB5A and CYB5R3

Data Source:
HPRD (in vitro)

		CYB5A	CYB5R3
Description		cytochrome b5 type A	cytochrome b5 reductase 3
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Hemoglobin Complex Membrane Azurophil Granule Lumen Nitric-oxide Synthase Complex
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Enzyme Binding Heme Binding Metal Ion Binding	Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Protein Binding AMP Binding ADP Binding Nitrite Reductase (NO-forming) Activity NAD Binding FAD Binding
	Biological Process	L-ascorbic Acid Metabolic Process Electron Transport Chain Response To Cadmium Ion Proton Transmembrane Transport	Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Blood Circulation L-ascorbic Acid Metabolic Process Neutrophil Degranulation
Pathways		Vitamin C (ascorbate) metabolism	Vitamin C (ascorbate) metabolism Phase I - Functionalization of compounds Neutrophil degranulation
Drugs		Dimethyl Propionate Ester Heme Chromium Chromic citrate Chromic nitrate Chromium gluconate Chromium nicotinate Chromous sulfate	NADH Flavin adenine dinucleotide Copper
Diseases		Methemoglobinemia	Methemoglobinemia
GWAS		Blood protein levels ( 30072576)	Initial pursuit acceleration ( 29064472)
Interacting Genes		14 interacting genes: CYB5R3 CYCS CYP17A1 CYP1A1 CYP1A2 CYP2A6 CYP2D6 CYP2E1 CYP2W1 CYP3A4 CYP4A11 POR SCD UGT1A4	61 interacting genes: ADAM33 AGTRAP AIG1 ALG8 AQP6 ASGR1 BNIP2 CDIPT CERS4 CNIH1 COL8A2 CSGALNACT2 CYB5A CYCS ELOVL4 FAM210B FAM3C FAXDC2 FUNDC2 FXYD3 GAST GPR152 GRM2 HBG2 HSD17B13 LAPTM5 LRCH4 MFSD6 NINJ1 NRM NSG1 NXPE3 ORMDL2 PNLIPRP1 REEP4 SLC10A1 SLC10A6 SLC13A3 SLC22A2 SLC35A4 SLC35B2 SLC38A7 SPP1 STOM TMEM115 TMEM14B TMEM14C TMEM201 TMEM31 TMEM51 TMEM60 TMEM79 TNF TNFRSF10C UBIAD1 VAMP1 VAMP4 VAMP5 VMP1 WFDC2 ZDHHC15
Entrez ID		1528	1727
HPRD ID		08941	08942
Ensembl ID		ENSG00000166347	ENSG00000100243
Uniprot IDs		A0A384ME44 P00167	P00387
PDB IDs		2I96	1M91 1UMK
Enriched GO Terms of Interacting Partners?
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