CTSG and SERPIND1

Data Source:
HPRD (in vitro)

		CTSG	SERPIND1
Description		cathepsin G	serpin family D member 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Stress Granule Secretory Granule Azurophil Granule Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Heparin Binding
	Biological Process	Angiotensin Maturation Protein Phosphorylation Proteolysis Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Extracellular Matrix Disassembly Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Neutrophil-mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide	Chemotaxis Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid	Ardeparin Zinc Sulodexide Copper Bemiparin Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Inherited thrombophilia
GWAS		Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)
Interacting Genes		30 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 CYSRT1 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PICK1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	4 interacting genes: APP CTSG ELANE F2
Entrez ID		1511	3053
HPRD ID		00289	00795
Ensembl ID		ENSG00000100448	ENSG00000099937
Uniprot IDs		P08311	P05546 Q8IVC0
PDB IDs		1AU8 1CGH 1KYN 1T32 6VTM	1JMJ 1JMO 2NAT 2NCU 2NCV 2NCW 6J12 6KBO 6KBV
Enriched GO Terms of Interacting Partners?
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