TLCD4 and NAT8

Data Source:
BioGRID (two hybrid)

		TLCD4	NAT8
Description		TLC domain containing 4	N-acetyltransferase 8 (putative)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component Endoplasmic Reticulum Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Molecular_function Protein Binding	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Cysteine-S-conjugate N-acetyltransferase Activity
	Biological Process	Biological_process Lipid Homeostasis	Glutathione Metabolic Process Positive Regulation Of Gene Expression Peptidyl-lysine N6-acetylation Response To Drug Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Amyloid-beta Metabolic Process
Pathways			Amyloid fiber formation
Drugs
Diseases
GWAS			Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Chronic kidney disease ( 20383146) Creatinine levels ( 20383145) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 23535967) Glomerular filtration rate (creatinine) ( 28452372) Hemoglobin levels ( 32327693) Metabolic traits ( 21886157) Metabolite levels ( 21931564) Metabolite levels (X-11787) ( 23934736) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 24625756 23093944) Urinary metabolite levels in chronic kidney disease ( 29545352 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Urinary metabolite ratios in chronic kidney disease ( 29545352) Urinary metabolites ( 26352407)
Interacting Genes		71 interacting genes: ADGRB3 ADGRE2 ARV1 ATP13A1 BNIP3 CACNG1 CCDC167 CDIPT CHPT1 CLCN7 CLEC7A CMTM5 COMT CTXN3 CXCL16 CYP4F2 CYP4F22 DHRSX EBP EMC6 EMP1 ERG28 FA2H FDFT1 FXYD6 FXYD6-FXYD2 GJB2 GOSR2 GYPA HMOX1 IGFBP5 KRT1 LNPEP MS4A13 MYG1 NAT8 NDUFA3 NINJ1 NKG7 ORMDL1 PMP22 PRAF2 PRRT2 REEP6 SCAMP5 SCD SEC22A SEC22B SERP1 SFXN1 SFXN3 SLC22A18 SLC41A1 SMAGP STATH STX12 SYNDIG1 SYNJ2BP TIMM23 TMEM115 TMEM120B TMEM19 TMEM229B TMEM237 TMEM60 TMIE TVP23B UBE2J1 VEZT YIPF1 YIPF4	29 interacting genes: ARL13B ATP6V0E1 BIK CD79A CERS4 CREB3L1 EBP FAM209A FFAR2 GOLT1A GPR152 HSD17B13 JPH1 LEPROTL1 LMNA MFSD14B MTIF3 REEP2 SAR1A SLC10A6 SMAD4 TGFBR1 TLCD4 TMEM143 TMEM14B TMEM31 TMX2 TSPAN31 YIPF4
Entrez ID		148534	9027
HPRD ID		08110	08413
Ensembl ID		ENSG00000152078	ENSG00000144035
Uniprot IDs		Q96MV1	Q9UHE5
PDB IDs
Enriched GO Terms of Interacting Partners?
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