NLRP4 and NLRC4

Data Source:
HPRD (in vitro)

		NLRP4	NLRC4
Description		NLR family pyrin domain containing 4	NLR family CARD domain containing 4
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GO Annotations	Cellular Component	Cytosol	Cytosol IPAF Inflammasome Complex
	Molecular Function	ATP Binding	Magnesium Ion Binding Protein Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Endopeptidase Activator Activity Caspase Binding
	Biological Process	Inflammatory Response Regulation Of Type I Interferon Production	Activation Of Innate Immune Response Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Positive Regulation Of Protein Processing Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Pyroptosis Activation Of Cysteine-type Endopeptidase Activity
Pathways		IRF3 mediated activation of type 1 IFN Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN	TP53 Regulates Transcription of Caspase Activators and Caspases The IPAF inflammasome The IPAF inflammasome
Drugs
Diseases
GWAS		Plasma anti-thyroglobulin levels ( 29678681)	Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Male-pattern baldness ( 28196072)
Interacting Genes		2 interacting genes: CHUK NLRC4	5 interacting genes: BCL10 CASP1 NLRP4 NOD2 PYCARD
Entrez ID		147945	58484
HPRD ID		09619	06014
Ensembl ID		ENSG00000160505	ENSG00000091106
Uniprot IDs		B2RCA1 Q96MN2	Q9NPP4
PDB IDs		4EWI	6K8J 6MKS 6N1I
Enriched GO Terms of Interacting Partners?
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