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ADRA1B and EZR
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
ADRA1B
EZR
Description
adrenoceptor alpha 1B
ezrin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Nuclear Membrane
Fibrillar Center
Ruffle
Immunological Synapse
Uropod
Extracellular Space
Cytoplasm
Endosome
Cytosol
Actin Filament
Plasma Membrane
Microvillus
Brush Border
Focal Adhesion
Actin Cytoskeleton
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Extrinsic Component Of Membrane
Filopodium
T-tubule
Cortical Cytoskeleton
Microvillus Membrane
Vesicle
Ruffle Membrane
Protein-containing Complex
Ciliary Basal Body
Cell Projection
Cell Body
Microspike
Plasma Membrane Raft
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Cell Tip
Extracellular Exosome
Cell Periphery
Astrocyte Projection
Schwann Cell Microvillus
Cytoplasmic Side Of Apical Plasma Membrane
Molecular Function
G Protein-coupled Receptor Activity
Alpha1-adrenergic Receptor Activity
Protein Binding
Protein Heterodimerization Activity
RNA Binding
Actin Binding
Protein Binding
Microtubule Binding
Protein C-terminus Binding
Protein Domain Specific Binding
Protein Kinase A Catalytic Subunit Binding
Protein Kinase A Regulatory Subunit Binding
Identical Protein Binding
S100 Protein Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Actin Filament Binding
Protein Kinase A Binding
ATPase Binding
Disordered Domain Specific Binding
Biological Process
Positive Regulation Of Heart Rate By Epinephrine-norepinephrine
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Positive Regulation Of Vasoconstriction
Regulation Of Cardiac Muscle Contraction
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Neuron-glial Cell Signaling
Negative Regulation Of Transcription By RNA Polymerase II
Intestinal D-glucose Absorption
Sphingosine-1-phosphate Receptor Signaling Pathway
Leukocyte Cell-cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Regulation Of Cell Size
Positive Regulation Of Gene Expression
Protein Kinase A Signaling
Gland Morphogenesis
Membrane To Membrane Docking
Microvillus Assembly
Astral Microtubule Organization
Actin Cytoskeleton Reorganization
Receptor Internalization
Regulation Of Microvillus Length
Negative Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Cellular Protein-containing Complex Localization
Positive Regulation Of Multicellular Organism Growth
Cortical Microtubule Organization
Establishment Of Epithelial Cell Apical/basal Polarity
Filopodium Assembly
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Protein Secretion
Negative Regulation Of T Cell Receptor Signaling Pathway
Actin Filament Bundle Assembly
Establishment Of Centrosome Localization
Establishment Of Endothelial Barrier
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Protein Localization To Plasma Membrane
Protein Localization To Cell Cortex
Regulation Of NIK/NF-kappaB Signaling
Regulation Of Organelle Assembly
Terminal Web Assembly
Positive Regulation Of Protein Localization To Early Endosome
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cellular Protein Catabolic Process
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways
Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Netrin-1 signaling
Recycling pathway of L1
Recycling pathway of L1
Drugs
Amphetamine
Midodrine
Ranolazine
Ziprasidone
Cabergoline
Ropinirole
Dapiprazole
Amitriptyline
Olanzapine
Alfuzosin
Clozapine
Norepinephrine
Mirtazapine
Phenylephrine
Loxapine
Prochlorperazine
Prazosin
Prazosin
Imipramine
Chlorpromazine
Chlorpromazine
Buspirone
Nortriptyline
Amoxapine
Clonidine
Doxazosin
Labetalol
Nicardipine
Verapamil
Epinephrine
Thioridazine
Phentolamine
Ergotamine
Tizanidine
Tamsulosin
Paroxetine
Methoxamine
Trimipramine
Risperidone
Modafinil
Fenoldopam
Dobutamine
Quinidine
Phenoxybenzamine
Maprotiline
Oxymetazoline
Ergoloid mesylate
Promethazine
Carvedilol
Carvedilol
Doxepin
Nefazodone
Desipramine
Terazosin
Escitalopram
Pergolide
Bromocriptine
Quetiapine
Aripiprazole
Paliperidone
Mephentermine
Methotrimeprazine
Dextroamphetamine
Dextroamphetamine
Phendimetrazine
Periciazine
Acepromazine
Thioproperazine
Dronedarone
R450
Epicept NP-1
Sertindole
Mianserin
Pizotifen
Silodosin
Ocaperidone
Droxidopa
Xylometazoline
Perospirone
Brexpiprazole
Dosulepin
Etoperidone
Lorpiprazole
Cirazoline
Synephrine
Arotinolol
Moxisylyte
Aranidipine
Pipamperone
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Indigotindisulfonic acid
Tiapride
Dihydroergocristine
Aripiprazole lauroxil
Diseases
GWAS
Diastolic blood pressure (
27841878
)
Plasma anti-thyroglobulin levels (
29678681
)
Psoriatic arthritis (
26626624
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Bladder cancer (smoking interaction) (
24662972
)
Blond vs. brown/black hair color (
30531825
)
Brown vs. black hair color (
30531825
)
Hair color (
29662168
)
Refractive error (
32231278
)
Interacting Genes
11 interacting genes:
ADRA1A
AP2M1
EZR
FLNC
GNA11
GNAQ
NOS1
PPP1R9B
PRKCA
SAG
STAT1
55 interacting genes:
ACTB
ACTC1
ADORA2B
ADRA1B
ARF6
ARHGDIB
CD44
CDH1
CDK5
CFTR
CLIC5
CTNNB1
DLG1
EGFR
ERBB3
FAS
FASLG
GZMM
ICAM1
ICAM2
ICAM3
IQGAP1
L1CAM
LCK
MDM2
MISP
MME
MPP3
MSN
NF2
PALLD
PIK3R1
PRKAR2A
PRKCA
PTK2
PTPRC
RDX
ROCK1
S100P
SCYL3
SDC2
SELL
SELP
SLC9A3R1
SLC9A3R2
SPN
SUMO2
TBC1D10A
TMEM8B
TSC1
USP1
VCAM1
VPS11
WFDC1
WWOX
Entrez ID
147
7430
HPRD ID
00080
00475
Ensembl ID
ENSG00000170214
ENSG00000092820
Uniprot IDs
P35368
P15311
PDB IDs
1NI2
4RM8
4RM9
4RMA
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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