NRG4 and LHFPL5

Data Source:
BioGRID (two hybrid)

		NRG4	LHFPL5
Description		neuregulin 4	LHFPL tetraspan subfamily member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Plasma Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Stereocilium Tip
	Molecular Function	Protein Binding Growth Factor Activity	Protein Binding
	Biological Process	MAPK Cascade Nervous System Development ERBB2 Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Motility	Ion Transport Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Sensory Perception Auditory Receptor Cell Stereocilium Organization
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Diastolic blood pressure ( 28270201) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Metabolite levels ( 23823483) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Serum uric acid levels ( 30993211) Systolic blood pressure ( 30224653 30578418) Urate levels ( 31578528 23263486) Urate levels in obese individuals ( 25811787)	Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494)
Interacting Genes		6 interacting genes: CISD2 CREB3 ERBB4 ERGIC3 FATE1 LHFPL5	127 interacting genes: ADGRG3 APOL3 AQP2 AQP6 AQP9 BTN2A2 C14orf180 C1GALT1 C3orf52 C5orf46 CD37 CD53 CD72 CD79A CD81 CDS2 CERS4 CLCN7 CLDN22 CLDN5 CLDND2 CLEC14A CMTM7 CREB3 CREB3L1 CTXN3 CXCL16 CYB561 DAGLA ELOVL4 EMP1 EMP3 ENTPD3 ERG28 ERGIC3 FAM209A FCGR1A FFAR2 FNDC9 FXYD6 GGT7 GJA8 GJB2 GJB3 GJB4 GJB6 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HAS3 HLA-DQA2 INSIG2 ITGB2 JAGN1 KASH5 KCNK5 KIR2DL3 KTN1 LAT LIME1 LMNA LNPEP LPAR3 LRRC25 LRRC4C MFF MFSD5 MIP MS4A13 MTIF3 NINJ2 NIPAL4 NKG7 NRG4 PDZK1IP1 PLLP PLP1 PLP2 RMDN3 RPRM RUSF1 SAR1A SEC22A SEC22B SERP1 SERP2 SERTM1 SLC16A2 SLC34A2 SLC35A1 SLC35B4 SLC35C2 SLC41A1 SMIM1 SYNJ2BP TEX264 TFRC TIMMDC1 TM4SF18 TM4SF4 TMEM100 TMEM107 TMEM128 TMEM201 TMEM218 TMEM229B TMEM248 TMEM254 TMEM31 TMEM42 TMEM50B TMEM52B TMEM60 TMEM86A TMEM97 TMX1 TMX2 TRARG1 TSPAN33 TSPAN7 TSPO UBIAD1 VAMP3 VMA21 ZDHHC15
Entrez ID		145957	222662
HPRD ID		14871	13989
Ensembl ID		ENSG00000169752	ENSG00000197753
Uniprot IDs		Q8WWG1	Q8TAF8
PDB IDs
Enriched GO Terms of Interacting Partners?
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