SPATA8 and COL8A1

Data Source:
BioGRID (two hybrid)

		SPATA8	COL8A1
Description		spermatogenesis associated 8	collagen type VIII alpha 1 chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Collagen Type VIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process		Angiogenesis Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Camera-type Eye Morphogenesis Epithelial Cell Proliferation
Pathways			Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Cerebrospinal fluid AB1-42 levels ( 26252872) Childhood ear infection ( 27182965 28928442) Chronotype ( 30696823) Cotinine glucuronidation ( 25293881) General risk tolerance (MTAG) ( 30643258) Health literacy ( 31250787) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Severe influenza A (H1N1) infection ( 26379185) Systemic lupus erythematosus ( 24871463)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636) Axial length ( 24144296) Childhood ear infection ( 27182965) Cleft lip with or without cleft palate ( 28054174) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Refractive error ( 32231278) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 31798171 25241763 28073927)
Interacting Genes		25 interacting genes: ADAMTSL4 CMTM5 COL8A1 CYSRT1 EFEMP2 FHL3 GOPC HNRNPF KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP6-2 KRTAP9-2 MDFI MKRN3 MLH1 MTUS2 NBPF19 NOTCH2NLA PLSCR1 PSMA3 RBPMS TEKT4 ZNF76	78 interacting genes: ADAMTSL4 ARMC5 BPIFA1 C11orf1 C19orf54 C22orf39 C9orf24 CCN3 CEP55 CIDEB COL8A2 CREB5 CYSRT1 DPEP2NB EFEMP2 FAM86C1P FBLN2 FBXO34 FRS3 GLRX3 GSC2 HOXA1 INCA1 ITGA1 ITGA2 KLHL12 KLHL20 KPRP KRT37 KRT40 KRT82 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP12-3 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-5 KRTAP19-7 KRTAP26-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-2 KRTAP6-3 KRTAP9-2 KRTAP9-3 LIMS1 MAJIN NADSYN1 NBPF19 NOTCH2NLA OTX1 PLSCR3 POF1B POU4F2 PPARA RBPMS REL RGS20 RHBDD2 SLC35A2 SP4 SPATA8 SPRY4 SSC4D TRIM35 UBQLN2 UBQLN4 VAC14 WFDC5 YPEL3 ZNF774 ZNHIT1
Entrez ID		145946	1295
HPRD ID		15432	00372
Ensembl ID		ENSG00000185594	ENSG00000144810
Uniprot IDs			P27658
PDB IDs
Enriched GO Terms of Interacting Partners?
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