CSF2RB and IL3

Data Source:
HPRD (in vivo, in vitro)

		CSF2RB	IL3
Description		colony stimulating factor 2 receptor subunit beta	interleukin 3
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Signaling Receptor Activity	Cytokine Activity Interleukin-3 Receptor Binding Growth Factor Activity
	Biological Process	MAPK Cascade Signal Transduction Respiratory Gaseous Exchange By Respiratory System Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Cellular Protein Metabolic Process	MAPK Cascade Regulation Of Cytokine-mediated Signaling Pathway Immune Response Cell-cell Signaling Nervous System Development Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Embryonic Hemopoiesis Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade RUNX1 regulates transcription of genes involved in interleukin signaling Interleukin receptor SHC signaling
Drugs		Sargramostim NPI 32101 Resatorvid	Amlexanox Zinc Polaprezinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)	Body mass index ( 28552196) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Inflammatory bowel disease ( 28067908 23128233) Perceived unattractiveness to mosquitoes ( 28199695) Rheumatoid arthritis ( 30423114 24390342) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ	5 interacting genes: CSF2RB HRAS IL3RA PIK3CA PIK3CD
Entrez ID		1439	3562
HPRD ID		00739	00987
Ensembl ID		ENSG00000100368	ENSG00000164399
Uniprot IDs		P32927 Q6NSJ8	P08700
PDB IDs		1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU	1JLI 5UV8 5UWC 6NMY
Enriched GO Terms of Interacting Partners?
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