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CSF1R and RASA1
Data Source:
HPRD
(in vivo)
CSF1R
RASA1
Description
colony stimulating factor 1 receptor
RAS p21 protein activator 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Intracellular Membrane-bounded Organelle
Receptor Complex
CSF1-CSF1R Complex
Ruffle
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Macrophage Colony-stimulating Factor Receptor Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Cytokine Binding
Protein Homodimerization Activity
Phosphotyrosine Residue Binding
GTPase Activity
GTPase Activator Activity
Signaling Receptor Binding
Protein Binding
Potassium Channel Inhibitor Activity
GTPase Binding
Biological Process
Positive Regulation Of Protein Phosphorylation
Hematopoietic Progenitor Cell Differentiation
Response To Ischemia
Inflammatory Response
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Positive Regulation Of Macrophage Chemotaxis
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Olfactory Bulb Development
Forebrain Neuron Differentiation
Hemopoiesis
Monocyte Differentiation
Macrophage Differentiation
Osteoclast Differentiation
Positive Regulation Of Cell Migration
Ruffle Organization
Positive Regulation Of Chemokine Production
Positive Regulation Of Kinase Activity
Cellular Response To Macrophage Colony-stimulating Factor Stimulus
Macrophage Colony-stimulating Factor Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Positive Regulation By Host Of Viral Process
Innate Immune Response
Regulation Of Bone Resorption
Cell-cell Junction Maintenance
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Phosphatidylinositol-mediated Signaling
Mammary Gland Duct Morphogenesis
Positive Regulation Of Protein Tyrosine Kinase Activity
Microglial Cell Proliferation
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Cytokine Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
MAPK Cascade
Mitotic Cytokinesis
Vasculogenesis
Negative Regulation Of Cell-matrix Adhesion
Negative Regulation Of Cell Adhesion
Signal Transduction
Regulation Of Cell Shape
Regulation Of Actin Filament Polymerization
Intracellular Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Ras Protein Signal Transduction
Ephrin Receptor Signaling Pathway
Blood Vessel Morphogenesis
Regulation Of RNA Metabolic Process
Pathways
Other interleukin signaling
Transcriptional Regulation by VENTX
Downstream signal transduction
EPHB-mediated forward signaling
EPHB-mediated forward signaling
VEGFR2 mediated cell proliferation
Regulation of RAS by GAPs
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Imatinib
Sunitinib
ABT-869
5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE
6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
Fostamatinib
Erdafitinib
Pexidartinib
Diseases
Choriocarcinoma
RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS
Blood protein levels (
30072576
28240269
)
Granulocyte percentage of myeloid white cells (
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Chronotype (
30696823
)
Macular thickness (
30535121
)
Major depressive disorder (
23377640
)
Openness (
21173776
)
Prostate cancer aggressiveness (
25939597
)
Type 2 diabetes (
30297969
)
Interacting Genes
23 interacting genes:
CBL
CSF1
CTDSP1
CTDSP2
FYN
GRAP2
GRB2
INPP5D
INPPL1
KIT
LAMC2
LYN
PIK3CA
PIK3R1
PIK3R2
RASA1
SHC1
SOCS1
SOCS3
SOS1
STAP2
THOC5
YES1
94 interacting genes:
ABL1
AFAP1L2
ANXA6
APC
APP
AR
ARHGAP1
ARHGAP5
AURKA
AURKB
BBS10
BCL10
BCR
BIRC5
BMPR1A
BUB1
CASP3
CASP7
CAV2
CD5
CDKN2A
CSF1R
CSK
DCC
DLC1
DNAJA3
DOK1
DOK2
DOK4
EGFR
EIF1
EPHA2
EPHB2
EPHB3
ERBB2
ERBB3
ERBB4
EZH2
FES
FGFR1
G3BP1
GAB1
GMCL1
GRB2
HCK
HRAS
HSPD1
HTT
IGF1R
INSR
KDR
KHDRBS1
KIT
LCK
LYN
MAGI1
MAP4K4
MET
MLH3
NCK1
NRAS
NTRK1
OLIG1
PAG1
PDE6D
PDGFRB
PIK3R1
PMS2
PTK2B
PTPRC
PTPRJ
PXN
RAB5A
RACK1
RAP1A
RB1
SERPINA4
SHC1
SLC9A2
SMAD2
SOCS3
SPSB1
SRC
STAU1
STK11
SYK
SYN1
TRMT2A
WWP1
WWP2
XRCC6
YES1
ZAP70
ZNF579
Entrez ID
1436
5921
HPRD ID
01269
00745
Ensembl ID
ENSG00000182578
ENSG00000145715
Uniprot IDs
P07333
P20936
Q59GK3
PDB IDs
2I0V
2I0Y
2I1M
2OGV
3BEA
3DPK
3KRJ
3KRL
3LCD
3LCO
4DKD
4HW7
4LIQ
4R7H
4R7I
4WRL
4WRM
6IG8
6N33
6T2W
1WER
1WQ1
2GQI
2GSB
2J05
2J06
2M51
4FSS
6PXB
6PXC
6WAX
6WAY
Enriched GO Terms of Interacting Partners
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