CRP and H2AC16

Data Source:
HPRD (in vivo, in vitro)

		CRP	H2AC16
Description		C-reactive protein	H2A clustered histone 16
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleosome Nucleus Extracellular Exosome
	Molecular Function	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding	DNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium	Chromatin Silencing Biological_process
Pathways		Classical antibody-mediated complement activation	HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases		Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 24763700 29403010 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Interacting Genes		21 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70	5 interacting genes: BRD7 CRP GADD45A SAP30 TERF2IP
Entrez ID		1401	8332
HPRD ID		00422	09103
Ensembl ID		ENSG00000132693	ENSG00000276903
Uniprot IDs		P02741	A4FTV9 P0C0S8
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO	4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7JO9 7JOA
Enriched GO Terms of Interacting Partners?
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