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CRK and SEMA4D
Data Source:
BioGRID
(two hybrid)
CRK
SEMA4D
Description
CRK proto-oncogene, adaptor protein
semaphorin 4D
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Actin Cytoskeleton
Membrane
Protein-containing Complex
Membrane Raft
Extracellular Exosome
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Molecular Function
Phosphotyrosine Residue Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Kinase Binding
Signaling Receptor Complex Adaptor Activity
Ubiquitin Protein Ligase Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Self-association
Protein Phosphorylated Amino Acid Binding
Ephrin Receptor Binding
Scaffold Protein Binding
Protein Tyrosine Kinase Binding
Transmembrane Signaling Receptor Activity
Signaling Receptor Binding
Protein Binding
Semaphorin Receptor Binding
Signaling Receptor Activity
Chemorepellent Activity
Biological Process
Activation Of MAPKK Activity
Neuron Migration
Response To Yeast
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Regulation Of Cell Shape
Regulation Of Signal Transduction
Positive Regulation Of Smooth Muscle Cell Migration
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Actin Cytoskeleton Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cell Adhesion Mediated By Integrin
Regulation Of Rac Protein Signal Transduction
Helper T Cell Diapedesis
Response To Hepatocyte Growth Factor
Reelin-mediated Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Response To Hydrogen Peroxide
Regulation Of GTPase Activity
Regulation Of Protein Binding
Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Dendrite Development
Cell Chemotaxis
Negative Regulation Of Wound Healing
Response To Cholecystokinin
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To Nitric Oxide
Activation Of GTPase Activity
Cerebellar Neuron Development
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Regulation Of Intracellular Signal Transduction
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Cellular Response To Endothelin
Negative Regulation Of Cell Motility
Regulation Of T Cell Migration
Negative Regulation Of Transcription By RNA Polymerase II
Neural Crest Cell Migration
Positive Regulation Of Protein Phosphorylation
Immune Response
Cell Adhesion
Negative Regulation Of Cell Adhesion
Axon Guidance
Regulation Of Cell Shape
Negative Regulation Of Alkaline Phosphatase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Cell Migration
Regulation Of Cell Projection Organization
Negative Regulation Of Apoptotic Process
Positive Regulation Of GTPase Activity
Ossification Involved In Bone Maturation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Collateral Sprouting
Regulation Of Dendrite Morphogenesis
Negative Regulation Of Axon Extension Involved In Axon Guidance
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Negative Chemotaxis
Leukocyte Aggregation
Semaphorin-plexin Signaling Pathway
Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis
Positive Regulation Of Inhibitory Synapse Assembly
Pathways
ARMS-mediated activation
ARMS-mediated activation
Downstream signal transduction
Regulation of actin dynamics for phagocytic cup formation
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
MET activates RAP1 and RAC1
MET receptor recycling
Regulation of signaling by CBL
FCGR3A-mediated phagocytosis
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Other semaphorin interactions
Drugs
Diseases
GWAS
Atrial fibrillation (
30061737
)
Granulocyte count (
27863252
)
Intraocular pressure (
30591961
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Pulse pressure (
27841878
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Systolic blood pressure (
28135244
27841878
30578418
)
Blood protein levels (
30072576
29875488
)
Body mass index (
28296344
)
Brain morphology (MOSTest) (
32665545
)
High light scatter reticulocyte count (
32888494
27863252
)
High light scatter reticulocyte percentage of red cells (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
27863252
)
Reticulocyte fraction of red cells (
32888494
27863252
)
Youthful appearance (self-reported) (
32339537
)
Interacting Genes
169 interacting genes:
ABL1
ABL2
ANKZF1
ANLN
AR
ARHGAP17
ARHGAP32
ASAP1
ASAP3
ASCL4
ATF3
ATXN1
AVIL
BATF3
BCAR1
BCR
BEX5
BUB1
C1orf94
C4orf17
C6orf141
CBL
CBLB
CBLC
CHTF18
CLNK
CNDP2
CORO6
CRKL
DAB1
DOCK1
DOCK3
DOK1
DOK2
DOK3
DOK4
DOK7
DPPA4
EFS
EGFR
ELK1
ELK3
EPHA3
EPHB2
EPHB3
EPHB6
EPS15
EPYC
ERBB2
ERBB3
ERBB4
ESD
EYA3
FASLG
FER
FGFR1
FLACC1
FLT1
FRS2
FSTL1
FYN
GAB1
GABPB2
GAREM1
GRB2
HABP4
HSH2D
IFT140
IGF1R
IKZF3
INO80E
INSR
IRS1
IRS2
IRS4
ISL1
KCTD13
KCTD17
KDR
KHDRBS1
KIT
KLF15
KLHL20
LASP1
LHX8
LNX2
MAGEC3
MAP4K1
MAP4K5
MAPK4
MAPK8
MET
MICAL1
MNDA
MPG
MYLIP
MYOZ2
NCK1
NEDD9
NTRK1
NUFIP2
OFCC1
PAFAH1B2
PDGFRA
PDGFRB
PHC2
PIK3R1
PIK3R2
PIK3R3
PLSCR1
POT1
PPFIBP2
PPP1CA
PRKACA
PRRC2B
PRRG2
PSMC1
PSMC6
PTK2
PTK2B
PTPN1
PTPN4
PTPRH
PTTG1
PXN
RAB2B
RAPGEF1
REPS1
RET
RIN3
RTCB
RYBP
SASH1
SAXO1
SEMA4D
SEPTIN6
SETD9
SH2D2A
SH3BP1
SHB
SHC1
SOCS1
SOCS6
SOS1
SPRR2A
STAT4
STAT5A
STAT5B
STRN4
SYN1
TCAP
TDG
TERF2IP
TM4SF19
TP53
TP53BP2
TUBA1C
TWIST2
TXK
USP53
VAC14
VAV1
WASF1
WDR83
WEE1
XPO1
ZAP70
ZKSCAN7
ZNF557
5 interacting genes:
CD72
CRK
LINC00839
PLXNB1
PTPRC
Entrez ID
1398
10507
HPRD ID
01267
03520
Ensembl ID
ENSG00000167193
ENSG00000187764
Uniprot IDs
A0A0S2Z3K9
A0A0S2Z3Q4
L7RT18
P46108
Q92854
PDB IDs
1JU5
2DVJ
2EYV
2EYW
2EYX
2EYY
2EYZ
2MS4
5UL6
6ATV
1OLZ
3OL2
Enriched GO Terms of Interacting Partners
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