COPB1 and ADAM19

Data Source:
HPRD (two hybrid)

		COPB1	ADAM19
Description		COPI coat complex subunit beta 1	ADAM metallopeptidase domain 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane COPI Vesicle Coat Transport Vesicle Secretory Granule Membrane Intracellular Membrane-bounded Organelle Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Nucleus Golgi Apparatus Plasma Membrane Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Structural Molecule Activity Protein Binding	Metalloendopeptidase Activity Protein Binding SH3 Domain Binding Metal Ion Binding Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process
	Biological Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Viral Process Neutrophil Degranulation	Placenta Development Membrane Protein Ectodomain Proteolysis Positive Regulation Of Gene Expression Protein Processing Extracellular Matrix Organization Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Invadopodia formation
Drugs
Diseases
GWAS		HDL cholesterol ( 26780889) HDL cholesterol levels ( 32203549 28334899) Height ( 31562340) High chromosomal aberration frequency (total) ( 31586183) Vitamin D levels ( 25208829)	Asthma ( 31959851) Blood protein levels ( 30072576) Body mass index ( 28552196) Chronic obstructive pulmonary disease ( 28166215 30804561) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FEV1/FVC) ( 28166213 30804560) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Pulmonary function ( 20010835) Pulmonary function (smoking interaction) ( 23284291) T-Cell Immunoglobulin and Mucin domain 1 levels ( 32460577) Triglyceride levels ( 31647587)
Interacting Genes		44 interacting genes: ADAM19 APP ARCN1 ARF1 BCAR1 COPE COPG1 COPG2 ERBIN FOXB1 GORAB GRB2 GTPBP4 HLA-DPB1 HLA-G ID1 IRAK3 KCNK3 KDELR1 KIAA1328 LINC00839 LZTS1 LZTS2 NUB1 PDGFRB PRKCE PTEN RGS2 RGS4 RHOQ SCYL1 SERTAD1 SNTA1 SPTBN1 TANK TAPBP TMED10 TRIM37 TTYH2 UBC UBQLN4 VPS18 WBP2 XRCC6	7 interacting genes: A2M ABI2 COPB1 FURIN NRG1 SH3GL2 TNFSF11
Entrez ID		1315	8728
HPRD ID		02981	04704
Ensembl ID		ENSG00000129083	ENSG00000135074
Uniprot IDs		P53618	Q8TBU7 Q9H013
PDB IDs
Enriched GO Terms of Interacting Partners?
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