TBC1D20 and APOC4

Data Source:
BioGRID (two hybrid)

		TBC1D20	APOC4
Description		TBC1 domain family member 20	apolipoprotein C4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Golgi Membrane Nuclear Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Lipid Transporter Activity Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Organization Virion Assembly Positive Regulation Of GTPase Activity Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell COPII Vesicle Coating COPII-coated Vesicle Cargo Loading Regulation Of Cilium Assembly Positive Regulation Of ER To Golgi Vesicle-mediated Transport	Lipid Metabolic Process Lipid Transport Positive Regulation Of Sequestering Of Triglyceride Very-low-density Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Clearance Triglyceride Homeostasis
Pathways		COPII-mediated vesicle transport TBC/RABGAPs	VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193043 18193044 20864672 19060906) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		7 interacting genes: ADRA1A APOC2 APOC4 APP AQP6 EBP TMEM14B	24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1
Entrez ID		128637	346
HPRD ID		15472	02848
Ensembl ID		ENSG00000125875	ENSG00000267467
Uniprot IDs		Q96BZ9 Q9Y2V8	P55056
PDB IDs		4HL4 4HLQ
Enriched GO Terms of Interacting Partners?
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