SYT2 and NAPB

Data Source:
BioGRID (two hybrid)

		SYT2	NAPB
Description		synaptotagmin 2	NSF attachment protein beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Chromaffin Granule Membrane Exocytic Vesicle	Vacuolar Membrane SNARE Complex Synapse Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Extracellular Exosome
	Molecular Function	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Inositol 1,3,4,5 Tetrakisphosphate Binding	Soluble NSF Attachment Protein Activity Protein Binding Syntaxin Binding
	Biological Process	Regulation Of Dopamine Secretion Vesicle-mediated Transport Calcium-ion Regulated Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Membrane Organization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Extension	Intracellular Protein Transport Regulation Of Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic SNARE Complex Disassembly
Pathways		Toxicity of botulinum toxin type B (botB) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs		Botulinum Toxin Type B
Diseases
GWAS		Celiac disease ( 23936387) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)	Factor VII activity ( 30642921)
Interacting Genes		29 interacting genes: AQP10 BNIP2 CCDC167 CLDN4 CMTM3 FA2H FUNDC2 ITGAM KLHL3 LAT MALL MIP NAPB NRXN1 ORMDL3 PLPP4 PMP22 SLC30A8 SLC35A1 SLC35A4 STON2 SYNCRIP TF THSD7B TMEM107 TMEM229B TSPO2 VAMP4 WNK1	31 interacting genes: ALOX5AP ARL6IP1 BET1 CISD2 CLEC10A CREB3L1 DGAT2L6 FAM209A GJB5 HSD17B13 KCNN3 LEUTX PLEKHO1 SDCBP SIGLEC5 SNAP23 SNAP29 STX16 STX19 STX1A STX1B STX2 STX3 STX4 STX5 STX6 SYT1 SYT2 TAF1B TFEC TMEM139
Entrez ID		127833	63908
HPRD ID		02520	17627
Ensembl ID		ENSG00000143858	ENSG00000125814
Uniprot IDs		Q8N9I0	A0A087WZQ7 Q9H115
PDB IDs
Enriched GO Terms of Interacting Partners?
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