C1orf216 and TPM1

Data Source:
BioGRID (two hybrid)

		C1orf216	TPM1
Description		chromosome 1 open reading frame 216	tropomyosin 1
Image		No pdb structure
GO Annotations	Cellular Component		Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane
	Molecular Function	Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process		Positive Regulation Of Heart Rate By Epinephrine Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways			Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases			Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS			Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 19820697 32888494 27863252) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494 27863252) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		71 interacting genes: ABI2 AIMP2 AMOT BORCS6 CCDC136 CCDC158 CCDC197 CDR2 CDR2L CENPH CEP170P1 CEP55 CMC2 DES DMAP1 EIF3F EXOC5 FSD2 GGA1 HAP1 HAUS8 IFT20 KLHL20 KRT13 KRT15 KRT16 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT38 KRT39 KRT40 KRT75 KRT76 LRRC61 MAGEA6 MDFI MED4 MIS18A MLPH MRFAP1L1 MTUS2 MYRIP NECAB2 NMI NRBF2 NUP62 ODAD1 PKNOX2 PPP1R16A PSMC6 RALBP1 SERTAD3 SNW1 SYCE1L THAP1 TLE5 TMCO5A TPM1 TPM3 TRAF1 TRIM54 TRIM72 USHBP1 VPS52 WASHC1 ZDHHC17 ZNF620	33 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCDC96 CCHCR1 CDC42 CLIP4 EGFR EPB41 FAM9C FGA GOLGA2 IFIT3 JUN KXD1 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4 WASHC1 YEATS4
Entrez ID		127703	7168
HPRD ID		08798	01839
Ensembl ID		ENSG00000142686	ENSG00000140416
Uniprot IDs		Q8TAB5	A0A024R5W6 A0A0K0K1I0 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H7BYY1 O15513 P09493
PDB IDs			3MUD 5KHT 6UT2 6X5Z
Enriched GO Terms of Interacting Partners?
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