ACKR2 and CCL3

Data Source:
HPRD (in vivo)

		ACKR2	CCL3
Description		atypical chemokine receptor 2	C-C motif chemokine ligand 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Recycling Endosome	Extracellular Region Extracellular Space Cytoplasm Cytosol
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding	Protein Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding Chemokine Activity Phospholipase Activator Activity Kinase Activity CCR1 Chemokine Receptor Binding CCR5 Chemokine Receptor Binding Chemoattractant Activity Identical Protein Binding CCR Chemokine Receptor Binding
	Biological Process	Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	MAPK Cascade Osteoblast Differentiation Cell Activation Monocyte Chemotaxis Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Response To Toxic Substance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Neutrophil Chemotaxis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Eosinophil Degranulation Protein Kinase B Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Astrocyte Cell Migration Negative Regulation By Host Of Viral Transcription Negative Regulation Of Osteoclast Differentiation Eosinophil Chemotaxis Macrophage Chemotaxis Lymphocyte Chemotaxis Positive Regulation Of Inflammatory Response Regulation Of Behavior Positive Regulation Of Calcium-mediated Signaling Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Granulocyte Chemotaxis Positive Regulation Of Calcium Ion Import Positive Regulation Of Microglial Cell Activation Positive Regulation Of Microglial Cell Migration Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines Interleukin-10 signaling
Drugs			ROX-888
Diseases
GWAS		Blood protein levels ( 29875488 28240269) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971)
Interacting Genes		24 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 CREB3 EFNA5 GJA8 MS4A1 NIPAL4 SACM1L SLC13A4 TMEM167B	11 interacting genes: ACKR2 CCL4 CCR1 CCR3 CCR4 CCR5 CEBPB SRGN TGFB1 UBQLN1 UBQLN2
Entrez ID		1238	6348
HPRD ID		09095	01656
Ensembl ID		ENSG00000144648	ENSG00000277632
Uniprot IDs		A1LP82 O00590	A0N0R1 P10147
PDB IDs			1B50 1B53 2X69 2X6G 3FPU 3H44 3KBX 4RA8 4ZKB 5COR 5D65
Enriched GO Terms of Interacting Partners?
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