CMA1 and EDN3

Data Source:
HPRD (in vitro)

		CMA1	EDN3
Description		chymase 1	endothelin 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Secretory Granule Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Peptide Binding	Signaling Receptor Binding Hormone Activity Endothelin B Receptor Binding
	Biological Process	Angiotensin Maturation Extracellular Matrix Disassembly Midbrain Development Basement Membrane Disassembly Positive Regulation Of Angiogenesis Regulation Of Inflammatory Response Cellular Response To Glucose Stimulus Cytokine Precursor Processing	Neural Crest Cell Migration Positive Regulation Of Leukocyte Chemotaxis Regulation Of Systemic Arterial Blood Pressure By Endothelin Cellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Multicellular Organism Development Blood Circulation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Regulation Of Gene Expression Cellular Magnesium Ion Homeostasis Artery Smooth Muscle Contraction Vein Smooth Muscle Contraction Regulation Of Vasoconstriction Peptide Hormone Secretion Neuron Differentiation Melanocyte Differentiation Neutrophil Chemotaxis Vasoconstriction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Hormone Secretion Inositol Phosphate-mediated Signaling Regulation Of Developmental Pigmentation Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways		Signaling by SCF-KIT Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Benzylsulfonic acid 2-(N-morpholino)ethanesulfonic acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid [(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACID
Diseases			Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS) Waardenburg syndrome (WS)
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hypertension ( 19430479 21909115) Metabolite levels ( 23823483) Response to diuretic therapy in hypertension ( 23753411) Systolic blood pressure ( 21909115 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858)
Interacting Genes		10 interacting genes: AGT EDN1 EDN2 EDN3 FYN IL1B KITLG MMP1 PFN1 SERPINA3	5 interacting genes: CMA1 CTSE EDNRA EDNRB KEL
Entrez ID		1215	1908
HPRD ID		00346	00570
Ensembl ID		ENSG00000092009	ENSG00000124205
Uniprot IDs		P23946 Q4FEB3	P14138 Q4FAT2
PDB IDs		1KLT 1NN6 1PJP 1T31 2HVX 3N7O 3S0N 4AFQ 4AFS 4AFU 4AFZ 4AG1 4AG2 4K2Y 4K5Z 4K60 4K69 4KP0 5YJM 5YJP	6IGK
Enriched GO Terms of Interacting Partners?
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