CLTB and HIP1R

Data Source:
HPRD (in vitro, two hybrid)

		CLTB	HIP1R
Description		clathrin light chain B	huntingtin interacting protein 1 related
Image		No pdb structure
GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Plasma Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Synaptic Vesicle Membrane Intracellular Membrane-bounded Organelle Clathrin-coated Endocytic Vesicle Ciliary Membrane Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone Cytoplasmic Component	Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Postsynaptic Density Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Synaptic Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Intracellular Protein Transport Clathrin Coat Assembly Membrane Organization Clathrin-dependent Endocytosis	Endocytosis Receptor-mediated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Binding Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Digestive System Development Regulation Of Gastric Acid Secretion Membrane Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Atrial fibrillation ( 30061737 29892015) Body mass index ( 29273807) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990)
Interacting Genes		9 interacting genes: CALM1 CLTC CSNK2A1 CSNK2A2 HIP1 HIP1R HTR4 MYO6 PQBP1	13 interacting genes: ACTA1 ACTB CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT NDC80 TFIP11 TRIM27
Entrez ID		1212	9026
HPRD ID		00352	10412
Ensembl ID		ENSG00000175416	ENSG00000130787
Uniprot IDs		A0A024R7S3 P09497	B3KQW8 B4DPL0 O75146
PDB IDs			1R0D
Enriched GO Terms of Interacting Partners?
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