CLNS1A and ITGA2B

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro, in vivo)

		CLNS1A	ITGA2B
Description		chloride nucleotide-sensitive channel 1A	integrin subunit alpha 2b
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cytoskeleton Plasma Membrane Methylosome PICln-Sm Protein Complex	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	RNA Binding Protein Binding	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Spliceosomal SnRNP Assembly Chloride Transport Cell Volume Homeostasis	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Extracellular Matrix Organization Regulation Of Megakaryocyte Differentiation Platelet Aggregation
Pathways		snRNP Assembly	Platelet degranulation Integrin cell surface interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Abciximab Tirofiban Lefradafiban Fradafiban
Diseases			Glanzmann thrombasthenia
GWAS		Diastolic blood pressure ( 30224653) Platelet distribution width ( 32888494) Tourette syndrome ( 30818990)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 32888494)
Interacting Genes		17 interacting genes: ACTB CSNK2A1 EIF4A2 EPB41 EPB41L3 FRMD7 ITGA2B LSM10 LSM3 LSM6 PRMT5 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPG WDR77	20 interacting genes: APP AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA FGG FN1 GRB2 ITGB3 PLA2G4A PRKACA SHARPIN TLN1 VWF
Entrez ID		1207	3674
HPRD ID		03694	06377
Ensembl ID		ENSG00000074201	ENSG00000005961
Uniprot IDs		E9PJF4 E9PMI6 J3KN38 P54105	P08514
PDB IDs		6V0O	1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2MTP 2N9Y 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4Z7N 4Z7O 4Z7Q 5HDB 6V4P
Enriched GO Terms of Interacting Partners?
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