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CGAS and RNF185
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
CGAS
RNF185
Description
cyclic GMP-AMP synthase
ring finger protein 185
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Site Of Double-strand Break
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Integral Component Of Membrane
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Protein Binding
ATP Binding
GTP Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Metal Ion Binding
Cyclic-GMP-AMP Synthase Activity
Protein Binding
Ubiquitin Binding
Ubiquitin-like Protein Conjugating Enzyme Binding
Protein-containing Complex Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Regulation Of Immunoglobulin Production
DNA Repair
Cellular Response To DNA Damage Stimulus
Determination Of Adult Lifespan
Positive Regulation Of CGMP-mediated Signaling
Viral Process
Positive Regulation Of Type I Interferon Production
Paracrine Signaling
Positive Regulation Of CAMP-mediated Signaling
Innate Immune Response
Regulation Of T Cell Activation
Defense Response To Virus
Cellular Response To Exogenous DsRNA
Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Cellular Senescence
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Ubiquitin-dependent ERAD Pathway
ERAD Pathway
Protein Autoubiquitination
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Positive Regulation Of ERAD Pathway
Endoplasmic Reticulum Mannose Trimming
Pathways
STING mediated induction of host immune responses
ABC-family proteins mediated transport
Defective CFTR causes cystic fibrosis
ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Fish- and plant-related diet (
32066663
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Waist circumference (
28552196
)
White blood cell count (
32888494
)
Interacting Genes
1 interacting genes:
RNF185
32 interacting genes:
APP
CGAS
CMTM5
CYB561A3
DVL2
FAM241B
MALL
MS4A13
MTNR1B
MYADML2
NIPAL4
RNF5
TMBIM6
TMEM147
TMEM19
TMEM86A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2I
UBE2K
UBE2V1
UBE2W
USP21
YIPF2
YIPF4
YIPF6
Entrez ID
115004
91445
HPRD ID
12857
08790
Ensembl ID
ENSG00000164430
ENSG00000138942
Uniprot IDs
Q8N884
A0A024R1F5
A0A024R1H4
Q96GF1
PDB IDs
4KM5
4LEV
4LEW
4MKP
4O67
4O68
4O69
5V8O
5VDO
5VDP
5VDQ
5VDR
5VDS
5VDT
5VDU
5VDV
5VDW
6CT9
6CTA
6EDB
6EDC
6LRC
6LRE
6LRI
6LRJ
6LRK
6LRL
6MJU
6MJW
6MJX
6NAO
6NFG
6NFO
6O47
6Y5D
6Y5E
7C0M
7CCQ
7CCR
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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