RHPN1 and TRIM37

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RHPN1	TRIM37
Description		rhophilin Rho GTPase binding protein 1	tripartite motif containing 37
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Peroxisome Cytosol Aggresome ESC/E(Z) Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Chromatin Binding Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of NF-kappaB Transcription Factor Activity Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Centriole Replication Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Aggresome Assembly
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Cognitive function ( 25644384) General cognitive ability ( 29844566) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)
Interacting Genes		17 interacting genes: CALCOCO2 CEP70 CNKSR1 EFEMP2 GOLGA2 GPRASP2 HAP1 KRT15 KRT31 LZTS1 MTUS2 RHOA ROPN1 TRIM27 TRIM37 TRIM55 TRIM63	73 interacting genes: ANKRD11 APEX2 APTX AQP1 ARNT2 AXIN1 BYSL CCDC33 CDC20B CDC7 CDK5RAP2 CDKL3 COPB1 CWF19L2 DDX6 DLGAP5 DTNB DZIP1L ELOA ELOA2 EWSR1 FAM107A FAM124B FAM161A FAM50B FXR2 H2AC20 H2AC4 IKBKG KAT5 KIAA0408 KIF9 LTBR MAGEB18 MCM10 MCRS1 NGFR NUDT18 PBK PNKP PRC1 RASD1 RHPN1 RIBC2 RNF6 RPL9 RXRB SCNM1 SYTL4 TCEANC TNFRSF1B TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 UBASH3A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2U ZBTB24 ZMAT2 ZNF329 ZNF417 ZNF587 ZNF655
Entrez ID		114822	4591
HPRD ID		17973	05463
Ensembl ID		ENSG00000158106	ENSG00000108395
Uniprot IDs		Q8TCX5	O94972
PDB IDs			3LRQ
Enriched GO Terms of Interacting Partners?
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