CHRNB4 and CHRNA5

Data Source:
HPRD (in vitro)

		CHRNB4	CHRNA5
Description		cholinergic receptor nicotinic beta 4 subunit	cholinergic receptor nicotinic alpha 5 subunit
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Specific Granule Membrane Neuron Projection Synapse Postsynaptic Membrane Tertiary Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Neuron Projection Synapse Postsynaptic Membrane Dopaminergic Synapse
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity Acetylcholine Binding Protein-containing Complex Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Neurotransmitter Receptor Activity
	Biological Process	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Regulation Of Membrane Potential Neutrophil Degranulation Regulation Of Neurotransmitter Secretion Nervous System Process Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition	Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential Regulation Of Synaptic Vesicle Exocytosis
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Butabarbital Fluoxetine Dextromethorphan Ethanol Pentolinium Levacetylmethadol Epibatidine	Nicotine Butabarbital Ethanol
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention function in attention deficit hyperactive disorder ( 26174813) Autism spectrum disorder or schizophrenia ( 28540026) Benign childhood epilepsy with centro-temporal spikes ( 32580138) BMI (smoking interaction) ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease ( 30804561) Coronary artery disease ( 32469254 33020668) Diffusing capacity of carbon monoxide ( 30694715) Exhaled carbon monoxide levels ( 25072098) Gut microbiota relative abundance (Parabacteroides) ( 33208821) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 18385738 18780872) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730) Sudden cardiac arrest ( 21658281)	Airflow obstruction ( 22837378) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 22080838 28166215 19300482 20173748) Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575) Diffusing capacity of carbon monoxide ( 30694715) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Exhaled carbon monoxide levels ( 25072098) Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) FagerstrÓ§m test for nicotine dependence ( 31294817) Local histogram emphysema pattern ( 25006744) Lung adenocarcinoma ( 28604730 19836008) Lung cancer ( 18385676 28604730 18385738 18780872 27393504) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Non-small cell lung cancer ( 31326317) Parental lifespan ( 30642433 29030599) Parental longevity (both parents in top 10%) ( 29227965) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (father's age at death) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Pre bronchodilator FEV1 ( 26634245) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718) Pulmonary function ( 21946350) Schizophrenia ( 25056061 29483656) Serum albumin level ( 23022100) Small cell lung carcinoma ( 28604730) Smoking behavior ( 22832964 20418889) Smoking behaviour (cigarettes smoked per day) ( 30679032) Smoking status (heavy vs light) ( 28520984) Time to smoke first cigarette in the morning ( 31294817) Urate levels ( 31578528) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 MEOX2 UBQLN1	1 interacting genes: CHRNB4
Entrez ID		1143	1138
HPRD ID		00337	00334
Ensembl ID		ENSG00000117971	ENSG00000169684
Uniprot IDs		P30926	H0YM98 P30532 Q6EWN4
PDB IDs		2ASG 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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